Biomarkers in Patients With Respiratory Tract Dysplasia or Lung Cancer, Head and Neck Cancer, or Aerodigestive Tract Cancer and in Normal Volunteers

Eligibility Criteria

• * Diagnosis of extensive and severe dysplasia of the respiratory epithelium
• * Those without dysplasia of the respiratory epithelium
• * Recruited from the SPORE Tissue Procurement Screening Project or by private or academic physicians (for patients with moderate or severe dysplasia)
• * Survived 1 or more aerodigestive system carcinoma for ≥ 1 year
• * Completely resected stage I non-small cell cancer
• * Undergoing any of the following procedures:
• * Routine panendoscopy for patients with head and neck cancer
• * Resection of a bronchogenic carcinoma
• * Bronchoscopy for diagnosis or staging of suspected lung cancer
• * Subsequent bronchoscopy for surveillance or monitoring of response to endobronchial treatment in patients with prior high-grade dysplasia or worse
• * No asthma
• * No lung disease
• * No respiratory illness within the past 2 weeks Patients suspected of or at risk for neoplastic lung disease who are undergoing a bronchoscopy in which differential diagnostic considerations may include multiple other etiologies such as infection and other processes.
• * No clinically apparent bleeding diathesis
• * No known bleeding disorder
• * No anginal
• * No clinically active coronary artery disease
• * No multifocal premature ventricular contractions
• * No poorly controlled congestive heart failure
• * No myocardial infarction within the past 6 weeks
• * No cardiac dysrhythmia that is potentially life threatening
• * Well-controlled atrial fibrillation or rare (\< 2/min) premature ventricular contractions allowed
• * No ventricular tachycardia or supraventricular tachycardia with a rapid ventricular response
• * No other serious medical condition that would preclude a patient from undergoing a bronchoscopy
• * No acute bronchitis or pneumonia within the past 8 weeks except when clinically proven as a possible result of lung cancer
• * No hypoxemia (i.e., \< 90% saturation with supplemental oxygen) before bronchoscopy
• * See Disease Characteristics