RECRUITING

Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research study is to examine the effect of cardiac sympathetic denervation (CSD) surgery on life threatening abnormal heart rhythms called ventricular tachycardia or ventricular fibrillation that can lead to sudden cardiac death. Subjects will be asked to participate in this research study if they have recurrent ventricular tachycardia (at least one ICD shock for ventricular tachycardia) and have undergone at least one catheter ablation procedure or have ventricular tachycardia or fibrillation that is not ablatable. The goal of this study is to determine whether cardiac sympathetic denervation can prevent these abnormal heart rhythms from occurring and therefore, prevent, ICD shocks which are not only painful, but have been shown to reduce quality of life and/or lead to depression, particularly in the period immediately after the shock.

Official Title

Prophylactic Cardiac Sympathetic Denervation for Prevention of Ventricular Tachyarrhythmias (PREVENT VT)

Quick Facts

Study Start:2021-07-26
Study Completion:2024-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01013714

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Marmar Vaseghi, MD, PhD
CONTACT
310-206-2235
mvaseghi@mednet.ucla.edu

Principal Investigator

Marmar Vaseghi, MD, PhD
PRINCIPAL_INVESTIGATOR
University of California, Los Angeles

Study Locations (Sites)

UCLA Health
Los Angeles, California, 90095
United States
OHSU
Portland, Oregon, 97239
United States
Vanderbilt University
Nashville, Tennessee, 37235
United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

  • Marmar Vaseghi, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-07-26
Study Completion Date2024-08-31

Study Record Updates

Study Start Date2021-07-26
Study Completion Date2024-08-31

Terms related to this study

Keywords Provided by Researchers

  • Sudden cardiac death
  • Ventricular tachycardia
  • Ventricular fibrillation
  • Cardiomyopathy
  • Internal cardiac defibrillator shocks
  • Internal cardiac defibrillator therapies

Additional Relevant MeSH Terms

  • Sudden Cardiac Death
  • Ventricular Tachycardia
  • Ventricular Fibrillation
  • Cardiomyopathy