TERMINATED

Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma

Conditions

Cardiac Arrest From Trauma trauma cardiac arrest hemorrhagic shock

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by delayed resuscitation with cardiopulmonary bypass.

Official Title

Emergency Preservation and Resuscitation for Cardiac Arrest From Trauma

Quick Facts

Study Start:2016-10

Study Completion:2025-11-21

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:TERMINATED

Study ID

NCT01042015

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Penetrating trauma with clinical suspicion of exsanguinating hemorrhage * At least 1 sign of life at the scene (pulse, respiratory efforts, spontaneous movements, reactive pupils) * Loss of pulse \<5 min prior to Emergency Department (ED) arrival or in ED or operating room * ED thoracotomy performed without immediate return of a palpable pulse in the carotid arteries after clamping the descending thoracic aorta	* No signs of life for \>5 min prior to the decision to initiate EPR * Obvious non-survivable injury * Suggestion of traumatic brain injury, such as significant facial or cranial distortion * Electrical asystole * Rapid external assessment of the injuries suggests massive tissue trauma or blunt trauma involving multiple body regions * Pregnancy * Prisoners

Inclusion Criteria

Exclusion Criteria

* Penetrating trauma with clinical suspicion of exsanguinating hemorrhage
* At least 1 sign of life at the scene (pulse, respiratory efforts, spontaneous movements, reactive pupils)
* Loss of pulse \<5 min prior to Emergency Department (ED) arrival or in ED or operating room
* ED thoracotomy performed without immediate return of a palpable pulse in the carotid arteries after clamping the descending thoracic aorta

* No signs of life for \>5 min prior to the decision to initiate EPR
* Obvious non-survivable injury
* Suggestion of traumatic brain injury, such as significant facial or cranial distortion
* Electrical asystole
* Rapid external assessment of the injuries suggests massive tissue trauma or blunt trauma involving multiple body regions
* Pregnancy
* Prisoners

Contacts and Locations

Principal Investigator

Samuel A Tisherman, MD

PRINCIPAL_INVESTIGATOR

University of Maryland, Baltimore

Study Locations (Sites)

University of Maryland

Baltimore, Maryland, 21201

United States

Collaborators and Investigators

Sponsor: University of Maryland, Baltimore

Samuel A Tisherman, MD, PRINCIPAL_INVESTIGATOR, University of Maryland, Baltimore

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-10

Study Completion Date2025-11-21

Study Record Updates

Study Start Date2016-10

Study Completion Date2025-11-21

Terms related to this study

Keywords Provided by Researchers

trauma
cardiac arrest
hemorrhagic shock

Additional Relevant MeSH Terms

Cardiac Arrest From Trauma