Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma

Description

The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by delayed resuscitation with cardiopulmonary bypass.

Conditions

Cardiac Arrest From Trauma

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Study Overview

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Study Details

Study overview

The goal of this study is to rapidly cool trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by delayed resuscitation with cardiopulmonary bypass.

Emergency Preservation and Resuscitation for Cardiac Arrest From Trauma

Emergency Preservation and Resuscitation (EPR) for Cardiac Arrest From Trauma

Condition
Cardiac Arrest From Trauma
Intervention / Treatment

-

Contacts and Locations

Baltimore

University of Maryland, Baltimore, Maryland, United States, 21201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Penetrating trauma with clinical suspicion of exsanguinating hemorrhage
  • * At least 1 sign of life at the scene (pulse, respiratory efforts, spontaneous movements, reactive pupils)
  • * Loss of pulse \<5 min prior to Emergency Department (ED) arrival or in ED or operating room
  • * ED thoracotomy performed without immediate return of a palpable pulse in the carotid arteries after clamping the descending thoracic aorta
  • * No signs of life for \>5 min prior to the decision to initiate EPR
  • * Obvious non-survivable injury
  • * Suggestion of traumatic brain injury, such as significant facial or cranial distortion
  • * Electrical asystole
  • * Rapid external assessment of the injuries suggests massive tissue trauma or blunt trauma involving multiple body regions
  • * Pregnancy
  • * Prisoners

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Maryland, Baltimore,

Samuel A Tisherman, MD, PRINCIPAL_INVESTIGATOR, University of Maryland, Baltimore

Study Record Dates

2025-12