Type 1 Diabetes Recurrence in Pancreas Transplants

Description

The hypothesis is that humoral and cellular islet-specific responses are an early risk factor for recurrence of autoimmunity and hyperglycemia in simultaneous pancreas-kidney (SPK) recipients independent of alloimmunity. This study will test the hypothesis and will assess their individual and combined predictive value.

Conditions

Diabetes Mellitus, Type 1

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Study Overview

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Study Details

Study overview

The hypothesis is that humoral and cellular islet-specific responses are an early risk factor for recurrence of autoimmunity and hyperglycemia in simultaneous pancreas-kidney (SPK) recipients independent of alloimmunity. This study will test the hypothesis and will assess their individual and combined predictive value.

Recurrence of T1D in Pancreas Transplantation

Type 1 Diabetes Recurrence in Pancreas Transplants

Condition
Diabetes Mellitus, Type 1
Intervention / Treatment

-

Contacts and Locations

Miami

University of Miami Miller School of Medicine Transplant Clinic, Miami, Florida, United States, 33136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient has been fully informed and has signed a dated IRB approval informed consent form and is willing to follow study procedures for the extent of the study (24 months). Parent or legal guardian must provide written consent for patients \<18 years of age.
  • * Age 18-75 years.
  • * Recipient of simultaneous pancreas and kidney transplant
  • * Primary or secondary renal allograft: living or deceased
  • * Patient has previously received or is receiving an organ transplant other than a pancreas-kidney.

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Miami,

George Burke, M.D., PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

2025-05