Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease

Description

Hypothesis: Tissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of heart disease. Tissue and serum samples collected from a limited numbers of "healthy controls" (donor grafts that were not utilized for heart transplantation) will serve as a comparator in research database projects. Design: This is a registry project; there are no investigational treatments, drug or procedures associated with participation in registry activities. This project is an organized functional data and tissue data gathering and storing (database) endeavor with specific focus on the functional, structural, and molecular aspects of heart failure. Data collection will not immediately influence the course of treatment for any patient.

Conditions

Congestive Heart Failure

Study Overview

Study Details

Study overview

Hypothesis: Tissue and serum samples collected from end-stage heart failure patients receiving left ventricular assist device implantation (LVAD) or heart transplantation will provide information regarding the basic science of heart disease. Tissue and serum samples collected from a limited numbers of "healthy controls" (donor grafts that were not utilized for heart transplantation) will serve as a comparator in research database projects. Design: This is a registry project; there are no investigational treatments, drug or procedures associated with participation in registry activities. This project is an organized functional data and tissue data gathering and storing (database) endeavor with specific focus on the functional, structural, and molecular aspects of heart failure. Data collection will not immediately influence the course of treatment for any patient.

Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease, Effects of Mechanical Unloading on Myocardial Function and Structure in Humans

Assessing Changes in Myocardial Tissue and Blood in Patients With Advanced Heart Disease

Condition
Congestive Heart Failure
Intervention / Treatment

-

Contacts and Locations

Murray

Intermountain Medical Center, Murray, Utah, United States, 84157

Salt Lake City

University of Utah Health Sciences Center, Salt Lake City, Utah, United States, 84132

Salt Lake City

VA Salt Lake City Health Care System, Salt Lake City, Utah, United States, 84148

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * \>18 years of age diagnosed with heart failure undergoing either LVAD implantation or heart transplantation
  • * 13 to 18 years of age, specifically, older children with heart failure whose body mass index is large enough to accommodate and LVAD
  • * Neither patient nor patient representative understands spoken English
  • * Neither patient nor patient's personal representative is willing to give written consent for participation.

Ages Eligible for Study

13 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Utah,

Stavros Drakos, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, University of Utah Health Sciences Center & VA Salt Lake City Health Care System

Study Record Dates

2028-01