RECRUITING

One-Time DNA Study for Vasculitis

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Conditions

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)Giant Cell ArteritisGranulomatosis With Polyangiitis (Wegener's)Microscopic PolyangiitisPolyarteritis NodosaTakayasu's ArteritisVasculitisCSSEGPAGCAGPAWGMPAPANTAK

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Official Title

VCRC Genetic Repository One-Time DNA Protocol

Quick Facts

Study Start:2010-10
Study Completion:2027-08
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01241305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:7 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Diagnostic criteria for Giant Cell Arteritis Age at disease onset \>50 years (required)
  2. 1. New onset or new type of localized pain in the head
  3. 2. Temporal artery abnormality (i.e. temporal artery tenderness to palpation or decreased pulsation, unrelated to arteriosclerosis of cervical arteries)
  4. 3. ESR of \>40mm in the first hour by the Westergren method
  5. 4. Abnormal artery biopsy (i.e. temporal artery biopsy showing vasculitis characterized by a predominance of mononuclear cell infiltration or granulomatous inflammation, usually with multinucleated giant cells)
  6. 5. Large Vessel Vasculitis (LVV) by angiogram or biopsy not explained by something else
  1. * Inability to give informed consent and to sign the consent form
  2. * Enrolled in VCRC protocols 5502, 5503, 5504, 5505, 5506, 5522, or 5523
  3. * Unwilling to provide blood for DNA collection

Contacts and Locations

Study Contact

Carol McAlear, MA
CONTACT
cmcalear@upenn.edu

Principal Investigator

Peter Merkel, MD, MPH
STUDY_DIRECTOR
University of Pennsylvania

Study Locations (Sites)

Cedars-Sinai Medical Center
Los Angeles, California, 90048
United States
University of California, San Francisco
San Francisco, California, 94143
United States
Northwestern University
Chicago, Illinois, 60208
United States
University of Kansas Medical Center
Kansas City, Kansas, 66103
United States
University of Michigan
Ann Arbor, Michigan, 48109-5422
United States
Mayo Clinic
Rochester, Minnesota, 55905
United States
Hospital for Special Surgery
New York, New York, 10021
United States
Cleveland Clinic
Cleveland, Ohio, 44195
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15261
United States
University of Utah
Salt Lake City, Utah, 84132
United States

Collaborators and Investigators

Sponsor: University of Pennsylvania

  • Peter Merkel, MD, MPH, STUDY_DIRECTOR, University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2010-10
Study Completion Date2027-08

Study Record Updates

Study Start Date2010-10
Study Completion Date2027-08

Terms related to this study

Keywords Provided by Researchers

  • Vasculitis
  • CSS
  • EGPA
  • GCA
  • GPA
  • WG
  • MPA
  • PAN
  • TAK

Additional Relevant MeSH Terms

  • Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)
  • Giant Cell Arteritis
  • Granulomatosis With Polyangiitis (Wegener's)
  • Microscopic Polyangiitis
  • Polyarteritis Nodosa
  • Takayasu's Arteritis