One-Time DNA Study for Vasculitis

Description

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Conditions

Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Giant Cell Arteritis, Granulomatosis With Polyangiitis (Wegener's), Microscopic Polyangiitis, Polyarteritis Nodosa, Takayasu's Arteritis

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Study Overview

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Study Details

Study overview

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

VCRC Genetic Repository One-Time DNA Protocol

One-Time DNA Study for Vasculitis

Condition
Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss)
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Cedars-Sinai Medical Center, Los Angeles, California, United States, 90048

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Chicago

Northwestern University, Chicago, Illinois, United States, 60208

Kansas City

University of Kansas Medical Center, Kansas City, Kansas, United States, 66103

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109-5422

Rochester

Mayo Clinic, Rochester, Minnesota, United States, 55905

New York

Hospital for Special Surgery, New York, New York, United States, 10021

Cleveland

Cleveland Clinic, Cleveland, Ohio, United States, 44195

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15261

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Diagnostic criteria for Giant Cell Arteritis Age at disease onset \>50 years (required)
  • 1. New onset or new type of localized pain in the head
  • 2. Temporal artery abnormality (i.e. temporal artery tenderness to palpation or decreased pulsation, unrelated to arteriosclerosis of cervical arteries)
  • 3. ESR of \>40mm in the first hour by the Westergren method
  • 4. Abnormal artery biopsy (i.e. temporal artery biopsy showing vasculitis characterized by a predominance of mononuclear cell infiltration or granulomatous inflammation, usually with multinucleated giant cells)
  • 5. Large Vessel Vasculitis (LVV) by angiogram or biopsy not explained by something else
  • * Inability to give informed consent and to sign the consent form
  • * Enrolled in VCRC protocols 5502, 5503, 5504, 5505, 5506, 5522, or 5523
  • * Unwilling to provide blood for DNA collection

Ages Eligible for Study

7 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

Peter Merkel, MD, MPH, STUDY_DIRECTOR, University of Pennsylvania

Study Record Dates

2027-08