Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

Description

The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the 129Xe apparent diffusion coefficient (ADC), and 3) imaging 129Xe that dissolves in the pulmonary blood and tissues upon inhalation. Such imaging of 129Xe gas transfer is expected to be uniquely sensitive to pathologies affecting gas exchange (fibrosis, emphysema, pulmonary hypertension) and provide new insights regarding the normal resting heterogeneity of pulmonary gas exchange.

Conditions

Interstitial Lung Disease

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Study Overview

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Study Details

Study overview

The purpose of this study is to develop and evaluate the usefulness of MRI using 129Xe gas for regional assessment of pulmonary function. Specifically, three forms of 129Xe MRI contrast will be the investigators focus - 1) imaging of the 129Xe ventilation distribution, 2) imaging the alveolar microstructure via the 129Xe apparent diffusion coefficient (ADC), and 3) imaging 129Xe that dissolves in the pulmonary blood and tissues upon inhalation. Such imaging of 129Xe gas transfer is expected to be uniquely sensitive to pathologies affecting gas exchange (fibrosis, emphysema, pulmonary hypertension) and provide new insights regarding the normal resting heterogeneity of pulmonary gas exchange.

Hyperpolarized 129Xe MR Imaging of the Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease

Hyperpolarized 129Xe MRI for Imaging Pulmonary Function

Condition
Interstitial Lung Disease
Intervention / Treatment

-

Contacts and Locations

Durham

Duke University Medical Center, Durham, North Carolina, United States, 27710

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Subject has no diagnosed pulmonary conditions
  • 2. Subject has not smoked in the previous 5 years.
  • 3. Smoking history, if any, is less than or equal to 5 pack-years.
  • 1. Subject has a diagnosis of pulmonary dysfunction made by a physician
  • 2. No acute worsening of pulmonary function in the past 30 days
  • 1. Subject is less than 18 years old
  • 2. MRI is contraindicated based on responses to MRI screening questionaire
  • 3. Subject is pregnant or lactating
  • 4. Respiratory illness of a bacterial or viral etiology within 30 days of MRI
  • 5. Subject has received an investigational medicinal product (not including 129Xe) within 30 days of MRI
  • 6. Subject has any form of known cardiac arrhythmia
  • 7. Subject does not fit into 129Xe vest coil used for MRI
  • 8. Subject cannot hold his/her breath for 15 seconds
  • 9. Subject deemed unlikely to be able to comply with instructions during imaging

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Bastiaan Driehuys,

Joseph Mammarappallil, M.D., PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2025-12