Vascularized Composite Allotransplantation for Multiple Extremity Amputations

Eligibility Criteria

• * Age between 18 and 60 years.
• * Single dominant hand or multiple limb amputation.
• * Time elapsed since amputation more than 6 months but less than 15 years.
• * Patient has tried prosthesis without success.
• * Level of amputation anywhere from the wrist (or ankle) joint to just below the shoulder (or hip) joint, which should be functional.
• * Signed written informed consent.
• * Willing to complete psychological and social evaluations.
• * Willing to take immunosuppressants - drugs that help prevent rejection of the transplant - for life.
• * Willing to comply with extensive post-transplant rehabilitation for a minimum of two years.
• * Willing to return for follow-up visits as determined by the treating physician.
• * Willing to receive standard vaccinations prior to the transplant, such as influenza and hepatitis B.
• * Single, non-dominant hand amputees.
• * Active malignancy.
• * High risk of return of malignancy.
• * History of persistent non-compliance.
• * Findings of psychological evaluation that indicate inability to comply with physician's orders or mental instability.
• * Any diagnosis that puts the subject at risk from limb transplant surgery or life-long immune suppression.
• * Inability to ensure adequate follow-up of post-transplant care and immune suppression.