Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Description

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Conditions

Sepsis, Severe Sepsis, Septic Shock, Multi-organ Failure

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Study Overview

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Study Details

Study overview

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Condition
Sepsis
Intervention / Treatment

-

Contacts and Locations

Houston

Memorial Hermann Hospital, Houston, Texas, United States, 77030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adults with severe sepsis or septic shock on mechanical ventilation
  • * Enrolled in the initial six hours of ICU admission
  • * Patients with withdrawal or hospice order.
  • * Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
  • * Patients with COPD.
  • * Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

The University of Texas Health Science Center, Houston,

Rosa M Estrada-Y-Martin, MD MSc, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center, Houston

Study Record Dates

2024-12