NOT_YET_RECRUITING

Alveolar Dead Space as Predictor of Organ Failure in Severe Sepsis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is an observational study to understand the changes in alveolar dead space in medical critically ill patients with severe infection (severe sepsis) requiring mechanical ventilation and the possibility to predict multi-organ failure. The measurement of alveolar dead space used to require sophisticated equipment and time. New ventilators have microprocessors that allow rapid mathematical calculation with minimal intervention.

Official Title

Alveolar Dead Space as Predictor of Multi-organ Failure and Mortality in Medical Intensive Care Patients With Sepsis Requiring Mechanical Ventilation

Quick Facts

Study Start:2026-12
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:NOT_YET_RECRUITING

Study ID

NCT01315782

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Adults with severe sepsis or septic shock on mechanical ventilation
  2. * Enrolled in the initial six hours of ICU admission
  1. * Patients with withdrawal or hospice order.
  2. * Patients with terminal, irreversible disease, expect to decease in 48 hours from ICU admission.
  3. * Patients with COPD.
  4. * Patients transferred from outside ICU with ongoing sepsis management for more than six hours.

Contacts and Locations

Study Contact

Rosa M Estrada-Y-Martin, MD MSc
CONTACT
713-500-6830
rosa.m.estrada.y.martin@uth.tmc.edu

Principal Investigator

Rosa M Estrada-Y-Martin, MD MSc
PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston

Study Locations (Sites)

Memorial Hermann Hospital
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: The University of Texas Health Science Center, Houston

  • Rosa M Estrada-Y-Martin, MD MSc, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center, Houston

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2026-12
Study Completion Date2026-12

Study Record Updates

Study Start Date2026-12
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • Sepsis
  • Severe sepsis
  • Septic shock
  • Alveolar dead space
  • Multi-organ failure

Additional Relevant MeSH Terms

  • Sepsis
  • Severe Sepsis
  • Septic Shock
  • Multi-organ Failure