Assessment of Eloquent Function in Brain Tumor Patients

Description

Purpose of the study: AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.

Conditions

Primary Brain Tumor, Metastatic Brain Tumor

Study Overview

Study Details

Study overview

Purpose of the study: AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.

Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors

Assessment of Eloquent Function in Brain Tumor Patients

Condition
Primary Brain Tumor
Intervention / Treatment

-

Contacts and Locations

Omaha

University of Nebraska Medical Center, Omaha, Nebraska, United States, 68198

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 19 years and older
  • * Brain tumor in or near eloquent brain regions that is appropriate for attempted resection
  • * Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping
  • * Benign or malignant intra-axial brain tumor
  • * Primary or metastatic intra-axial brain tumor
  • * Any contraindication to MRI (i.e. implanted devices)
  • * Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner
  • * Declining to participate
  • * Lacks capacity to understand the study or consent for themselves
  • * Neurologic status which precludes testing (poor function- not testable)
  • * Positive pregnancy test
  • * End stage renal disease or severe renal dysfunction

Ages Eligible for Study

19 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Nebraska,

Michele Aizenberg, MD, PRINCIPAL_INVESTIGATOR, University of Nebraska

Study Record Dates

2027-12