RECRUITING

Assessment of Eloquent Function in Brain Tumor Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Purpose of the study: AIM 1: Prospectively collect pre-operative \[functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), magnetoencephalography (MEG)\] and intra-operative mapping data in patients with intra-axial brain tumors to assess how well each modality predicts the location of eloquent brain function. In addition, each modality will be compared with the other. AIM 2: Assess reorganization of eloquent brain function and plasticity in patients with intra-axial brain tumors. This will be accomplished by prospectively collecting post-operative mapping studies and neuropsychological tests to compare them to prior mapping studies as stated above.

Official Title

Assessment of Reorganization and Plasticity of Eloquent Function in Patients With Brain Tumors

Quick Facts

Study Start:2012-01-31
Study Completion:2027-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01535430

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:19 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * 19 years and older
  2. * Brain tumor in or near eloquent brain regions that is appropriate for attempted resection
  3. * Appropriate body habitus and mental status/capacity to participate with non-invasive or invasive mapping
  4. * Benign or malignant intra-axial brain tumor
  5. * Primary or metastatic intra-axial brain tumor
  1. * Any contraindication to MRI (i.e. implanted devices)
  2. * Inappropriate body habitus or mental status/capacity to participate with non-invasive or invasive mapping in a safe and reliable manner
  3. * Declining to participate
  4. * Lacks capacity to understand the study or consent for themselves
  5. * Neurologic status which precludes testing (poor function- not testable)
  6. * Positive pregnancy test
  7. * End stage renal disease or severe renal dysfunction

Contacts and Locations

Study Contact

Dulce Maroni, PhD
CONTACT
402-836-9751
dmaroni@unmc.edu
Katie Maire, MS
CONTACT
402-559-6895
kmaire@unmc.edu

Principal Investigator

Michele Aizenberg, MD
PRINCIPAL_INVESTIGATOR
University of Nebraska

Study Locations (Sites)

University of Nebraska Medical Center
Omaha, Nebraska, 68198
United States

Collaborators and Investigators

Sponsor: University of Nebraska

  • Michele Aizenberg, MD, PRINCIPAL_INVESTIGATOR, University of Nebraska

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2012-01-31
Study Completion Date2027-12

Study Record Updates

Study Start Date2012-01-31
Study Completion Date2027-12

Terms related to this study

Keywords Provided by Researchers

  • brain mapping
  • brain tumor

Additional Relevant MeSH Terms

  • Primary Brain Tumor
  • Metastatic Brain Tumor