RECRUITING

Development of Radiation Free Whole Body Magnetic Resonance (MR) Imaging Technique for Staging Children With Cancer

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

A research study on the diagnosis of spread of disease for children who have been diagnosed with solid tumors using a new whole body imaging technique and a new MR contrast agent (ferumoxytol). Standard tests that are used to determine the extent and possible spread of a child's disease include magnetic resonance (MR) imaging, computed tomography (CT), Positron Emission Tomography (PET) as well as bone scanning, and metaiodobenzylguanidine (MIBG) scanning. The purpose of this study is to determine if newer imaging tests referred to as whole body diffusion-weighted MR and whole body PET/MR can detect the extent and spread of the disease as accurately or even better as the standard tests (CT, MR and/or PET/CT). The advantage of the new imaging test is that it is associated with no or significantly reduced radiation exposure compared to standard CT and PET/CT imaging tests. The results of whole body MR and PET/MR will be compared with that of the conventional, standard imaging studies for tumor detecting.

Official Title

Development of Radiation Free Whole Body MR Imaging Technique for Staging of Children With Cancer.

Quick Facts

Study Start:2012-02
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01542879

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:6 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of a solid extra-cranial tumor like malignant lymphoma or malignant sarcoma and
  2. * Scheduled for or completed a 18F-FDG-PET or 18F-FDG-PET/CT tumor staging procedure.
  3. * There will be no restrictions on prior treatment.
  4. * Very young children who need sedation or anesthesia will be excluded from the study.
  5. * In this pediatric \& adult study, the participant or parent/guardian is consented, and the patient when a minor is given an assent form and involved in the discussion as appropriate.
  1. * MR-incompatible metal implants,
  2. * need of sedation or claustrophobia.
  3. * Hemosiderosis/hemochromatosis (patients can still be included in 2nd branch without ferumoxytol)
  4. * There will be restrictions regarding use of other Investigational Agents: Pt with iron-overload will not receive Ferumoxytol
  5. * History of allergic reactions to similar compounds will be obtained and patients with a positive history of allergic reaction to iron compounds or other severe allergic reactions.will be excluded from the study.
  6. * Pregnant women and fetuses.

Contacts and Locations

Study Contact

Lucia Barrato
CONTACT
415 307 1990
lbaratto@stanford.edu

Principal Investigator

Heike Daldrup-Link
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Stanford University Cancer Institute
Stanford, California, 94305
United States

Collaborators and Investigators

Sponsor: Heike E Daldrup-Link

  • Heike Daldrup-Link, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2012-02
Study Completion Date2026-12

Study Record Updates

Study Start Date2012-02
Study Completion Date2026-12

Terms related to this study

Additional Relevant MeSH Terms

  • Cancer