RECRUITING

Sympathetic Overactivity in Post-traumatic Stress Disorder

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension. One potential mechanism is overactivation of the sympathetic nervous system (SNS), both at rest and particularly during stress. This study will evaluate whether 8 weeks of daily DGB therapy or transcutaneous vagus nerve stimulation (tVNS) therapy improves SNS activity at rest and during stress.

Official Title

Mechanisms of Sympathetic Overactivity in Post-traumatic Stress Disorder

Quick Facts

Study Start:2012-07
Study Completion:2024-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01627301

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Prehypertensive and normotensive veterans with PTSD, and prehypertensive and normotensive veterans without PTSD (controls)
  1. * heart or vascular disease
  2. * illicit drug use
  3. * excessive alcohol use (\>2 drinks per day)
  4. * pregnancy
  5. * autonomic dysfunction
  6. * medications known to affect SNS (clonidine)
  7. * treatment with monoamine oxidase (MAO) inhibitors within the last 14 days
  8. * any serious systemic disease

Contacts and Locations

Study Contact

Deirdre Dixon, MS
CONTACT
404-321-6111
deirdre.dixon@emory.edu
Jeanie Park, MD
CONTACT
404-321-6111

Principal Investigator

Jeanie Park, MD
PRINCIPAL_INVESTIGATOR
Emory University and the Atlanta VA Medical Center

Study Locations (Sites)

Atlanta VA Medical Center
Decatur, Georgia, 30033
United States

Collaborators and Investigators

Sponsor: Emory University

  • Jeanie Park, MD, PRINCIPAL_INVESTIGATOR, Emory University and the Atlanta VA Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2012-07
Study Completion Date2024-12

Study Record Updates

Study Start Date2012-07
Study Completion Date2024-12

Terms related to this study

Additional Relevant MeSH Terms

  • Post-traumatic Stress Disorder
  • Prehypertension