Tissue Collection for Studies of Lymph Cancer

Eligibility Criteria

• * Patients with a known lymphoid malignancy or precursor disease to a lymphoid malignancy, including multiple myeloma, B-cell and T-cell lymphomas: including but not limited to diffuse large B-cell lymphoma (DLBCL), Hodgkin s lymphoma (HL), multiple myeloma (MM), lymphomatoid granulomatosis (LYG) and adult T-cell leukemia/lymphoma (ATL).
• * Confirmation of pathological diagnosis is required from the Laboratory of Pathology, NCI. Tumor tissue that has been previously collected and is available for study or that can be collected with minimal additional risk to the subject during sampling required for routine patient care or required testing on an NIH research protocol will be used for diagnosis.
• * Age \>= 18 years of age
• * ECOG performance 0-2
• * Ability of patient or Legally Authorized Representative (LAR) to understand and the willingness to sign a written informed consent document NOTE: Patients enrolling with a LAR must be co-enrolled on another study.
• * Hemoglobin \>= 10 mg/dL and platelet count \> 75 K/uL
• * Weight greater than 25 kg
• * HIV negative
• * Prothrombin Time - within normal limits
• * Partial Thromboplastin Time - within normal limits
• * Medically indicated central line in place or adequate peripheral venous access
• * Pregnant individuals will not be eligible.
• * Active symptomatic major organ disorder that would increase the risk of biopsy or apheresis, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, pulmonary dysfunction.
• * Active concomitant medical or psychological illnesses that may increase the risk to the subject or inability to obtain informed consent, at the discretion of the principal investigator.