Electronic Cigarettes and Reactivity to Smoking Cues

Eligibility Criteria

• 1. Provide written informed consent.
• 2. Be aged 18-45.
• 3. Report smoking cigarettes daily in the past 6 months.
• 4. Have expired breath CO indicative of regular smoking.
• 5. Have a score greater than 0 on the FTND.
• 6. Be willing to use Nicotine Replacement Therapy (NRT) and the e-cigarette for a period of 2 to 3 weeks.
• 7. Speak and read English.
• 8. Pass an MRI safety screen and meet inclusion criteria for MRI scans.
• 1. Be pregnant (measured via urinalysis).
• 2. Meet current abuse or dependence criteria for any substance other than nicotine or caffeine (measured via the SCID 5).
• 3. Produce a positive urine screen for drugs of abuse or alcohol at the fMRI scan visits.
• 4. Meet DSM-IV criteria for major depressive episode in the past six months, lifetime DSM-IV diagnosis of organic mental disorder, schizophrenia, schizoaffective disorder, bipolar disorder, delusional disorder or psychotic disorders not elsewhere classified (measured via the SCID 5).
• 5. Be currently suicidal as assessed by DSM 5 and the Beck Depression Inventory.
• 6. Current use of medications or any history of a medical condition that might affect the central nervous system at the time of scanning including: Abnormal structural MRI, or a history of head trauma or injury causing loss of consciousness lasting longer than 3 minutes or associated with skull fracture or intracranial bleeding or who had irremovable magnetically active objects on or within their body, history of epilepsy, current use of a beta-blocker or prescription analgesic/anxiolytic. (assessed by self-report).
• 7. MRI exclusion criteria. (additional information outlined in the "protection of human subjects" section).
• 8. History of claustrophobia.
• 9. History of propylene glycol sensitivity/allergy.