Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository

Description

The Morphea in Adults and Children (MAC) cohort is the first registry for both children and adults with morphea (also known as localized scleroderma) in the country. The purpose of the registry is to learn more about morphea, specifically: * How morphea behaves over time * How frequently specific problems occur along with morphea (for example, arthritis) * Whether morphea has an autoimmune background

Conditions

Scleroderma, Localized, Morphea, Frontal Linear Scleroderma en Coup de Sabre, Scleroderma, Circumscribed, Scleroderma, Linear

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Study Overview

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Study Details

Study overview

The Morphea in Adults and Children (MAC) cohort is the first registry for both children and adults with morphea (also known as localized scleroderma) in the country. The purpose of the registry is to learn more about morphea, specifically: * How morphea behaves over time * How frequently specific problems occur along with morphea (for example, arthritis) * Whether morphea has an autoimmune background

Immunologic and Genetic Profiles in Subsets of Morphea Patients

Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository

Condition
Scleroderma, Localized
Intervention / Treatment

-

Contacts and Locations

Dallas

UT Southwestern Medical Center - Department of Dermatology, Dallas, Texas, United States, 75390-9069

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patient must have a clinical diagnosis of morphea confirmed by the primary investigator and by histopathological examination.
  • 2. Ages 0-90 years old
  • 3. Children must weigh more than 20 lbs. in order to satisfy Children's Medical Center policy for the maximum amount of blood drawn in a 24 hour period.
  • 4. Patient or legal guardian must be able to speak and read at a 6th grade reading level.
  • 5. Both male and female patients will be eligible
  • 6. All races and ethnic backgrounds will be included
  • 7. Relationships to proband: All patients with morphea will be included. A patient's family history will be reviewed and if there is a family history of morphea or systemic sclerosis then we will give the study patient the investigator's contact information and ask the family member to call the study team to answer any questions and enroll them in the study if they choose to do so.
  • 8. Ability to give informed consent: Patients must be able to give informed consent or they will give assent with parent or guardian consent as a minor to be a part of the morphea registry.

Ages Eligible for Study

to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Heidi Jacobe, MD, MSCS, PRINCIPAL_INVESTIGATOR, University of Texas Southwestern Medical Center

Study Record Dates

2028-01