Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

Description

The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.

Conditions

Alpha-1 Antitrypsin Deficiency, AAT Deficiency, AATD, Cystic Fibrosis (CF)

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Study Overview

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Study Details

Study overview

The purpose of this study is to look at how Alpha-1-antitrypsin (AAT) deficiency and Cystic Fibrosis (CF) affect white blood cells in the lungs, called macrophages, and their ability to work.

The Role of Conformational Diseases on Macrophage Function

Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs

Condition
Alpha-1 Antitrypsin Deficiency
Intervention / Treatment

-

Contacts and Locations

Gainesville

Shands at the University of Florida, Gainesville, Florida, United States, 32610

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Signed informed consent
  • * Male or female 18 years of age or older
  • * Negative pregnancy test for women of childbearing potential
  • * Hemoglobin \>12.5 g/dl measured on the day of participation
  • * Negative urine nicotine test
  • * Pregnancy or breastfeeding
  • * Weight \< 50 kg
  • * History of anemia requiring blood transfusions, erythropoietin supplementation, or iron supplementation within the past 36 months
  • * Known hemoglobin \<12.5 g/dl within the past 90 days
  • * Systolic blood pressure \> 180 mmHg and/or diastolic blood pressure \>100 mmHg
  • * Poor venous access
  • * Large volume blood donation (\>200 ml or 7 ounces) within the previous 56 days (e.g. blood donation for the purposes of blood banking)
  • * Clinically significant cardiac, hemostatic or neurological impairment or any other significant medical condition that, in the opinion of the investigator would affect subject safety (e.g., recent myocardial infarction, history of prolonged bleeding time, cerebral vascular accident, advanced cancer or uncontrolled medical condition)
  • * Psychiatric or cognitive disturbance or illness that would affect subject safety
  • * Current smoker

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Florida,

Karina Serban, MD, PRINCIPAL_INVESTIGATOR, University of Florida, College of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine

Study Record Dates

2033-07-20