Ovarian Tissue Transplantation

Description

Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol 806062). The primary objective of this study is to determine the efficacy and safety of autologous transplantation of previously cryopreserved ovarian cortical tissue in patients who experience infertility or ovarian insufficiency after cancer treatments.

Conditions

Infertile Females or Females With Ovarian Insufficiency

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Study Overview

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Study Details

Study overview

Chemotherapy and radiation therapy for the treatment of cancer can compromise fertility. Ovarian tissue cryopreservation is an experimental strategy offered at The University of Pennsylvania to preserve future fertility (protocol 806062). The primary objective of this study is to determine the efficacy and safety of autologous transplantation of previously cryopreserved ovarian cortical tissue in patients who experience infertility or ovarian insufficiency after cancer treatments.

Autologous Orthotopic Transplantation of Previously Cryopreserved Ovarian Tissue

Ovarian Tissue Transplantation

Condition
Infertile Females or Females With Ovarian Insufficiency
Intervention / Treatment

-

Contacts and Locations

Philadelphia

Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female patient between the ages of 18 and 45 years
  • * Previously cryopreserved and stored cortical ovarian tissue available for autologous transplantation
  • * Ovarian insufficiency defined as an elevated FSH over 10
  • * Inability to conceive after 6 months of unprotected intercourse with male
  • * Reasonably good health
  • * Candidate for pregnancy
  • * Written clearance for the procedure from the patients oncologist
  • * Patients considered to be high risk for surgical complications will be excluded from the research protocol
  • * Women who are known to be positive for the BRCA mutation
  • * Women with a history of leukemia, ovarian cancer or a cancer that likely involved the ovaries at the time of ovarian tissue collection
  • * Women with psychological, psychiatric, or other conditions which prevent giving fully informed consent
  • * Current pregnancy

Ages Eligible for Study

18 Years to 45 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Abramson Cancer Center at Penn Medicine,

Clarisa R Gracia, MD, PRINCIPAL_INVESTIGATOR, Abramson Cancer Center at Penn Medicine

Study Record Dates

2028-12