Safety of Pentoxifylline and Vitamin E With Stereotactic Ablative Radiotherapy (SABR) in Non-small Cell Lung Cancers

Eligibility Criteria

• 3.1.1 Age \>/= 18 years
• 3.1.2 ECOG performance status 0-1 3.1.3 Histologically proven diagnosis of a prior thoracic malignancy treated with thoracic external beam radiotherapy with or without systemic chemotherapy
• 3.1.4 Pathologic or clinical diagnosis of a new or loco-regional recurrent lung malignancy. A reasonable attempt should be made to make a pathologic diagnosis of malignancy (ie. bronchoscopy, CT guided lung biopsy)
• * Loco-regional is defined as recurrence within the region of the primary tumor or adjacent draining lymph node regions.
• * The new lesion or loco-regional recurrence must be within or adjacent to the previously irradiated treatment volume.
• 3.1.5 Imaging as follows:
• * CT scan of the chest with IV contrast within 8 weeks of registration
• * Whole body PET scan within 8 weeks of registration
• 3.1.6 Pulmonary function test (PFTs), including diffusion capacity within 8 weeks of registration
• 3.1.7 Negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential.
• 3.1.6 Women of childbearing potential and male participants who are sexually active must agree to use a medically effective means of birth control
• 3.1.7 Patients must provide study specific informed consent prior to study entry.
• 3.2.1. No previously reported thoracic radiotherapy
• 3.2.2. FEV1 \<20% predicted and/or DLCO \<20% predicted
• 3.2.2. Pregnant women or lactating women
• 3.2.3 Chemotherapy within 4 weeks of the initiation of SABR
• 3.2.4 Plans to administer systemic chemotherapy overlapping with radiotherapy