Hormonal, Metabolic, and Signaling Interactions in PAH

Description

Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.

Conditions

Idiopathic Pulmonary Arterial Hypertension, Heritable Pulmonary Arterial Hypertension, Scleroderma Associated Pulmonary Arterial Hypertension, Appetite Suppressant Associate PAH

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Study Overview

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Study Details

Study overview

Our hypothesis is that optimal treatment of the dysfunctional metabolic pathways which underlie PAH will improve pulmonary vascular function and consequences of the disease.

Hormonal, Metabolic, and Signaling Interaction in Pulmonary Arterial Hypertension

Hormonal, Metabolic, and Signaling Interactions in PAH

Condition
Idiopathic Pulmonary Arterial Hypertension
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Diagnosis of IPAH (idiopathic pulmonary arterial hypertension), HPAH (heritable pulmonary arterial hypertension), or APAH (associated pulmonary arterial hypertension), family members of affected persons
  • 2. Age 0-90, age 12-90 for skin biopsy
  • 1. Other diagnosis
  • 2. Age greater than 90, age less than 12 or greater than 90 for skin biopsy
  • 1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
  • 2. 0-90
  • 3. Subjects with reasonably easy access to clinic for blood collection and other testing
  • 4. Subject able to tolerate fasting state prior to sample collection and EndoPAT (endothelial function assessment) testing
  • 1. Other diagnosis
  • 2. 0-90
  • 3. Subjects with difficulty reaching clinic for blood collection and other testing
  • 4. Subjects unable to tolerate fasting state
  • 1. Diagnosis of IPAH, HPAH, or APAH, family members of affected persons
  • 2. 7-90
  • 1. Other diagnosis
  • 2. Age less than 7 or greater than 90

Ages Eligible for Study

to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Vanderbilt University Medical Center,

James E Loyd, MD, PRINCIPAL_INVESTIGATOR, Vanderbilt University Medical Center

Study Record Dates

2032-07