RECRUITING

The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Antibiotics are sometimes prescribed to patients who have had reconstructive surgery of wounds on their face using skin grafts. But, it is not yet known whether antibiotics improve the healing of skin grafts and reduce the risk of infections after surgery in these patients. It is known that antibiotics, like all medications, have side-effects although these are rare. This research study is designed to show us whether antibiotics improve wound healing or not, so that we may determine if we should continue using antibiotics even if they have side-effects in some patients. Our hypothesis is that patients treated with post-operative, systemic antibiotics will demonstrate a statistically significant improvement in the survival of their facial full thickness skin grafts compared to patients who are not treated with systemic antibiotics.

Official Title

The Role of Antibiotics in Full Thickness Skin Graft Survival for Facial Reconstructive Surgery

Quick Facts

Study Start:2013-07
Study Completion:2026-09
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT01912651

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * all adult patients with a nasal or facial skin/soft tissue defect requiring reconstruction limited to or including a full-thickness skin graft
  1. * current or recent (within one week of surgery) systemic antibiotic use, intolerance to both clindamycin and cephalexin, discovery of a persistent cutaneous malignancy at the site of the defect following the reconstructive procedure and previous reconstruction at the site of the skin/soft-tissue defect.

Contacts and Locations

Study Contact

Jeffrey S Moyer, MD
CONTACT
734-936-8051
jmoyer@med.umich.edu

Principal Investigator

Jeffrey Y Moyer, MD
PRINCIPAL_INVESTIGATOR
University of Michigan Otolaryngology

Study Locations (Sites)

University of Michigan
Ann Arbor, Michigan, 48109
United States

Collaborators and Investigators

Sponsor: University of Michigan

  • Jeffrey Y Moyer, MD, PRINCIPAL_INVESTIGATOR, University of Michigan Otolaryngology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2013-07
Study Completion Date2026-09

Study Record Updates

Study Start Date2013-07
Study Completion Date2026-09

Terms related to this study

Keywords Provided by Researchers

  • facial skin wound
  • facial wound
  • skin wound
  • facial defect
  • reconstructive skin graft

Additional Relevant MeSH Terms

  • Facial Defect