Functional and Structural Imaging for Glaucoma

Description

The specific aims of the clinical studies are to: * Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion. * Validate wide-field OCT and OCT angiography parameters to improve early glaucoma detection. * Simulate visual field results by combining structural and angiography OCT data. * Assess abilities of above technologies and OCT-derived parameters on predicting glaucoma detection, conversion, and progression.

Conditions

Glaucoma

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Study Overview

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Study Details

Study overview

The specific aims of the clinical studies are to: * Develop a directional high-resolution OCT and OCT angiography prototype to improve imaging of structure and perfusion. * Validate wide-field OCT and OCT angiography parameters to improve early glaucoma detection. * Simulate visual field results by combining structural and angiography OCT data. * Assess abilities of above technologies and OCT-derived parameters on predicting glaucoma detection, conversion, and progression.

Longitudinal Observational Study Using Functional and Structural Optical Coherence Tomography to Diagnose and Guide Treatment of Glaucoma

Functional and Structural Imaging for Glaucoma

Condition
Glaucoma
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Health & Science University, Casey Eye Institute, Portland, Oregon, United States, 97214

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. No history or evidence of retinal pathology or glaucoma
  • 2. Normal Humphrey 24-2 VF: A mean defect (MD), corrected pattern standard deviation (CPSD) within 95% limits of normal reference, and glaucoma hemifield test (GHT) within normal limits (97%).
  • 3. Intraocular pressure \< 21 mm Hg
  • 4. Central corneal pachymetry \> 500 microns
  • 5. No chronic ocular or systemic corticosteroid use
  • 6. Open angle (gonioscopy must show 75% or more of the angle to be Grade 2 or more by Shaffer's grading system)
  • 7. Normal appearing ONH and NFL: vertical and horizontal cup/disc ratio (CDR) ≤ 0.5 and intact neuroretinal rim without peripapillary hemorrhages, notches, localized pallor, or NFL defect
  • 8. Symmetric ONH between left and right eyes: CDR difference \< 0.2 in both vertical and horizontal dimensions
  • 1. Best-corrected visual acuity less than 20/40
  • 2. Age \< 40 or \>85 years
  • 3. Refractive error of \> +3.00 D or \< -7.00 D
  • 4. Previous intraocular surgery except for uncomplicated keratorefractive surgery and cataract extraction with posterior chamber intraocular lens implantation
  • 5. Diabetic retinopathy
  • 6. Other diseases that may cause VF loss or optic disc abnormalities
  • 7. Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil
  • 8. Inability to perform reliably on automated VF testing
  • 9. Life-threatening or debilitating illness making it unlikely patient could successfully complete the study.
  • 10. Refusal of informed consent or of commitment to the full length of the study

Ages Eligible for Study

40 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Oregon Health and Science University,

Aiyin Chen, MD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2026-05