RECRUITING

The Cancer of the Pancreas Screening-5 CAPS5)Study

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Conditions

Pancreas CancerPeutz-Jeghers Syndrome (PJS)Gene MutationGermline Mutation CarrierLynch Syndromefamilial pancreas cancer(Peutz-Jeghers Syndrome) PJSBreast cancer (BRCA) 2Partner and Locator of BRCA2 (PALB2)Familial Atypical Multiple Mole- Melanoma (FAMMM)p16, CDKN2ABreast Cancer (BRCA)1(hereditary non-polyposis colorectal cancer or Lynch syndrome) HNPCChereditary pancreatitisProtease Serine (PRSS)Chymotrypsin C (CTRC)Ataxia Telangiectasia Mutated(ATM)

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

Official Title

The Cancer of the Pancreas Screening-5 CAPS5)Study

Quick Facts

Study Start:2014-01-06
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02000089

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Hereditary Pancreatitis or
  2. * Peutz-Jeghers Syndrome or
  3. * Strong family history of pancreas cancer on one side of the family tree or
  4. * Confirmed germline mutation carrier (BRCA2, FAMMM (CDKN2A/p16), PALB2, BRCA1, ATM, HNPCC, Lynch Syndrome (hMLH1, hMSH2, PMS2, hMSH6, EpCAM) PRSS1, PRSS2, R122H, N291l, SPINK1, CFTR
  5. * Endoscopic evaluation of pancreas scheduled
  1. * Medical comorbidities or coagulopathy that contraindicate endoscopy
  2. * Prior surgery that prevent optimal endoscopic ultrasound such as partial or complete gastrectomy with Bilroth or Roux-en-Y anastomosis
  3. * Stricture or obstruction in the upper GI tract that does not allow passage of the echoendoscope
  4. * Poor performance status
  5. * Inability to provide informed consent
  6. * Pregnancy.

Contacts and Locations

Study Contact

Hilary Cosby, RN
CONTACT
hcosby1@jhmi.edu

Principal Investigator

Michael Goggins, MD
PRINCIPAL_INVESTIGATOR
Johns Hopkins University

Study Locations (Sites)

Yale University
New Haven, Connecticut, 06520
United States
Johns Hopkins Hospital
Baltimore, Maryland, 21287
United States
Dana Farber Cancer Center, Harvard University
Boston, Massachusetts, 02215
United States
University of Michigan
Ann Arbor, Michigan, 48109
United States
Columbia University Medical Center
New York, New York, 10032
United States
Case Comprehensive Cancer Center, Case Western Medical Reserve
Cleveland, Ohio, 44106
United States
University of Pennsylvania
Philadelphia, Pennsylvania, 19104
United States
University of Pittsburgh
Pittsburgh, Pennsylvania, 15213
United States

Collaborators and Investigators

Sponsor: Johns Hopkins University

  • Michael Goggins, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2014-01-06
Study Completion Date2025-12

Study Record Updates

Study Start Date2014-01-06
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • familial pancreas cancer
  • (Peutz-Jeghers Syndrome) PJS
  • Breast cancer (BRCA) 2
  • Partner and Locator of BRCA2 (PALB2)
  • Familial Atypical Multiple Mole- Melanoma (FAMMM)
  • p16, CDKN2A
  • Breast Cancer (BRCA)1
  • (hereditary non-polyposis colorectal cancer or Lynch syndrome) HNPCC
  • Lynch Syndrome
  • hereditary pancreatitis
  • Protease Serine (PRSS)
  • Chymotrypsin C (CTRC)
  • Ataxia Telangiectasia Mutated(ATM)

Additional Relevant MeSH Terms

  • Pancreas Cancer
  • Peutz-Jeghers Syndrome (PJS)
  • Gene Mutation
  • Germline Mutation Carrier
  • Lynch Syndrome