The Cancer of the Pancreas Screening-5 CAPS5)Study

Description

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

Conditions

Pancreas Cancer, Peutz-Jeghers Syndrome (PJS), Gene Mutation, Germline Mutation Carrier, Lynch Syndrome

Study Overview

Study Details

Study overview

Johns Hopkins clinical research office quality assurance group will monitor and audit this study at Johns Hopkins. The Sub Investigator at each site will be responsible for internal monitoring at their site.

The Cancer of the Pancreas Screening-5 CAPS5)Study

The Cancer of the Pancreas Screening-5 CAPS5)Study

Condition
Pancreas Cancer
Intervention / Treatment

-

Contacts and Locations

New Haven

Yale University, New Haven, Connecticut, United States, 06520

Baltimore

Johns Hopkins Hospital, Baltimore, Maryland, United States, 21287

Boston

Dana Farber Cancer Center, Harvard University, Boston, Massachusetts, United States, 02215

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

New York

Columbia University Medical Center, New York, New York, United States, 10032

Cleveland

Case Comprehensive Cancer Center, Case Western Medical Reserve, Cleveland, Ohio, United States, 44106

Philadelphia

University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Pittsburgh

University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Hereditary Pancreatitis or
  • * Peutz-Jeghers Syndrome or
  • * Strong family history of pancreas cancer on one side of the family tree or
  • * Confirmed germline mutation carrier (BRCA2, FAMMM (CDKN2A/p16), PALB2, BRCA1, ATM, HNPCC, Lynch Syndrome (hMLH1, hMSH2, PMS2, hMSH6, EpCAM) PRSS1, PRSS2, R122H, N291l, SPINK1, CFTR
  • * Endoscopic evaluation of pancreas scheduled
  • * Medical comorbidities or coagulopathy that contraindicate endoscopy
  • * Prior surgery that prevent optimal endoscopic ultrasound such as partial or complete gastrectomy with Bilroth or Roux-en-Y anastomosis
  • * Stricture or obstruction in the upper GI tract that does not allow passage of the echoendoscope
  • * Poor performance status
  • * Inability to provide informed consent
  • * Pregnancy.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins University,

Michael Goggins, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2025-12