RECRUITING

Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Our group has recently identified the association between gut-flora-mediated carnitine and phosphatidylcholine metabolism, specifically trimethylamine-N-oxide (TMAO), and cardiovascular risk. This study investigates the ability for dietary intervention to modulate TMAO levels.

Official Title

Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)

Quick Facts

Study Start:2014-04-04
Study Completion:2026-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02016430

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Jennifer Wilcox
CONTACT
216-636-6153
kirsopj@ccf.org
Timothy Engelman, LPN
CONTACT
216-636-6153
engelmt@ccf.org

Principal Investigator

W. H. Wilson Tang, MD
PRINCIPAL_INVESTIGATOR
The Cleveland Clinic
Stanley L. Hazen, MD
PRINCIPAL_INVESTIGATOR
The Cleveland Clinic

Study Locations (Sites)

Cleveland Clinic
Cleveland, Ohio, 44195
United States

Collaborators and Investigators

Sponsor: The Cleveland Clinic

  • W. H. Wilson Tang, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic
  • Stanley L. Hazen, MD, PRINCIPAL_INVESTIGATOR, The Cleveland Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2014-04-04
Study Completion Date2026-12

Study Record Updates

Study Start Date2014-04-04
Study Completion Date2026-12

Terms related to this study

Keywords Provided by Researchers

  • TMAO
  • Gut Flora
  • Dietary Intervention
  • Choline
  • Carnitine

Additional Relevant MeSH Terms

  • Dietary Modification
  • Cardiovascular Risk Factor