Celiac Disease Genomic Environmental Microbiome and Metabolomic Study

Description

Celiac disease (CD) is a complex disease caused by eating gluten, a protein contained in wheat, rye, and barley. It is well known that many factors contribute to the development of CD, including the genes that you have and the foods that you eat. In the CDGEMM study, we will consider as many of these factors as possible and study how they each contribute to disease development. If the investigators find that any one factor, or combination of factors, increases the risk of developing CD, we will be able to apply this information and help prevent or detect disease in high-risk children in the future.

Conditions

Celiac Disease

Study Overview

Study Details

Study overview

Celiac disease (CD) is a complex disease caused by eating gluten, a protein contained in wheat, rye, and barley. It is well known that many factors contribute to the development of CD, including the genes that you have and the foods that you eat. In the CDGEMM study, we will consider as many of these factors as possible and study how they each contribute to disease development. If the investigators find that any one factor, or combination of factors, increases the risk of developing CD, we will be able to apply this information and help prevent or detect disease in high-risk children in the future.

Celiac Disease Genomic Environmental Microbiome and Metabolomic (CDGEMM) Study

Celiac Disease Genomic Environmental Microbiome and Metabolomic Study

Condition
Celiac Disease
Intervention / Treatment

-

Contacts and Locations

Boston

Massachusetts General Hospital for Children, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Newborns and infants less than 6 months of age who have not been introduced to solid foods (exclusive breast milk or formula diet)
  • * First-degree relatives of patients affected with biopsy-proven CD
  • * Infants older than 6 months of age
  • * Inability or unwillingness of legal guardian/representative to give written informed consent

Ages Eligible for Study

to 6 Months

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Massachusetts General Hospital,

Alessio Fasano, MD, PRINCIPAL_INVESTIGATOR, Massachusetts General Hospital

Maureen M. Leonard, MD, STUDY_CHAIR, Massachusetts General Hospital

Study Record Dates

2025-12