RECRUITING

Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the subchondral bone marrow to the site of cartilage loss. The second method is the application of adipose-derived stem cells (ADSCs) to the defect site. In theory, ADSCs on a collagen scaffold should enable the delivery of more specific progenitor cells to the site of injury, resulting in better regeneration and integration of articular cartilage at the site of a defect as compared to the microfracture method.

Official Title

Randomized Controlled Trial of Microfracture Versus Adipose Derived Stem Cells for the Treatment of Isolated Articular Cartilage Defects

Quick Facts

Study Start:2015-11
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02090140

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Must be between ages 18 and 50 years.
  2. * Must have a discrete, contained chondral defect less than 400mm\^2 located on the medial or lateral femoral condyle
  3. * Must have overall neutral lower limb mechanical alignment (\<5 degrees varus or valgus).
  1. * Ages younger than 18 years and older than 50 years.
  2. * If they have undergone previous chondral procedures
  3. * If they have pre-existing osteoarthritis (Kellegren-Lawrence Grade ≥2)
  4. * If they have a BMI \>30.

Contacts and Locations

Study Contact

Kaitlyn Whitney
CONTACT
(720) 872-4836
Inverness.clinicaltrials@cuanschutz.edu

Principal Investigator

Jason Dragoo, MD
PRINCIPAL_INVESTIGATOR
University of Colorado - Anschutz Medical Campus
Seth L Sherman, MD
PRINCIPAL_INVESTIGATOR
Stanford University

Study Locations (Sites)

Stanford Medical Outpatient Center
Redwood City, California, 94063
United States
Kerlan Jobe Orthopedic Institute
Santa Monica, California, 90404
United States
UC Health Steadman Hawkins Clinic - Denver Inverness
Denver, Colorado, 80112
United States

Collaborators and Investigators

Sponsor: University of Colorado, Denver

  • Jason Dragoo, MD, PRINCIPAL_INVESTIGATOR, University of Colorado - Anschutz Medical Campus
  • Seth L Sherman, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2015-11
Study Completion Date2025-12

Study Record Updates

Study Start Date2015-11
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • cartilage/transplantation
  • cartilage, articular/injuries
  • cartilage, articular/surgery
  • chondrocytes/cytology
  • knee injuries/surgery
  • knee joint/surgery
  • orthopedic procedures/methods
  • tissue engineering
  • tissue scaffolds
  • arthroscopy/methods
  • chondrocytes/transplantation
  • adipose tissue/cytology
  • cartilage, articular/cytology
  • chondrogenesis/physiology
  • osteogenesis/physiology
  • stem cell transplantation/methods
  • stem cells
  • tissue engineering/methods
  • cartilage, articular/pathology
  • chondrocytes/pathology
  • knee joint/pathology
  • platelet-rich plasma

Additional Relevant MeSH Terms

  • Degenerative Lesion of Articular Cartilage of Knee