The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the subchondral bone marrow to the site of cartilage loss. The second method is the application of adipose-derived stem cells (ADSCs) to the defect site. In theory, ADSCs on a collagen scaffold should enable the delivery of more specific progenitor cells to the site of injury, resulting in better regeneration and integration of articular cartilage at the site of a defect as compared to the microfracture method.
Degenerative Lesion of Articular Cartilage of Knee
The purpose of this study is to compare two biologic methods for the treatment of articular cartilage defects in the knee. The first method, microfracture, is the standard of care and is routinely used to recruit cells from the subchondral bone marrow to the site of cartilage loss. The second method is the application of adipose-derived stem cells (ADSCs) to the defect site. In theory, ADSCs on a collagen scaffold should enable the delivery of more specific progenitor cells to the site of injury, resulting in better regeneration and integration of articular cartilage at the site of a defect as compared to the microfracture method.
Microfracture Versus Adipose Derived Stem Cells for the Treatment of Articular Cartilage Defects
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Stanford Medical Outpatient Center, Redwood City, California, United States, 94063
Kerlan Jobe Orthopedic Institute, Santa Monica, California, United States, 90404
UC Health Steadman Hawkins Clinic - Denver Inverness, Denver, Colorado, United States, 80112
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
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18 Years to 50 Years
ALL
No
University of Colorado, Denver,
Jason Dragoo, MD, PRINCIPAL_INVESTIGATOR, University of Colorado - Anschutz Medical Campus
Seth L Sherman, MD, PRINCIPAL_INVESTIGATOR, Stanford University
2025-12