RECRUITING

Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Background: \- Lung cancer is the leading cause of cancer-related death worldwide. It causes more than one million deaths every year. Researchers want to gather tissue samples from people with lung and thymic cancers to understand the disease better. This may lead to new ways to diagnose and treat it. Objective: \- To collect tissue samples for use in the study of lung cancers. Eligibility: \- Adults over age 18 with non-small cell lung cancer, small cell lung cancer, extra pulmonary small cell cancer, pulmonary neuroendocrine tumors, and thymic epithelial tumors. Design: * Participants will be screened with a medical history, physical exam, and blood tests. They will be asked about how they perform their daily tasks. * Participants may be asked to give urine and blood samples. They may give a saliva sample if they cannot give blood. They will also give a sample of their tumor from a biopsy they had. They may also be given the option to undergo a biopsy. * Participants may have MRI, CT, and/or PET scans of the body. They will lie in a machine that takes pictures of the body. * After visits to the Clinical Center end, researchers will contact participants by phone every year to check on their health.

Official Title

Tissue Procurement and Natural History Study of Patients With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors

Quick Facts

Study Start:2014-05-28
Study Completion:2029-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02146170

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Individuals with histologically or cytologically confirmed NSCLC, SCLC, ESCC, PNET, and TET.
  2. * Individuals consulted in the Clinical Center without a definitive diagnosis, but clinically considered likely to have a malignancy of the above histologies, pending further tissue acquisition and/or pathology review.
  3. * Age greater than or equal to18 years. Children are excluded from the study, as the above thoracic malignancies are rare in this population.
  4. * Ability of subject to understand and the willingness to sign a written informed consent document.
  1. * Active symptomatic major organ disorder that would increase the risk of biopsy, including but not limited to ischemic heart disease, recent myocardial infarction, active congestive heart failure, pulmonary dysfunction.
  2. * Active concomitant medical or psychological illnesses that may increase the risk to the subject, at the discretion of the Principal Investigator.
  3. * Known HIV-positive individuals not on combination antiretroviral therapy are ineligible.

Contacts and Locations

Study Contact

Shannon G Swift, R.N.
CONTACT
(240) 858-3157
shannon.swift@nih.gov
Arun Rajan, M.D.
CONTACT
(240) 760-6236
rajana@mail.nih.gov

Principal Investigator

Arun Rajan, M.D.
PRINCIPAL_INVESTIGATOR
National Cancer Institute (NCI)

Study Locations (Sites)

National Institutes of Health Clinical Center
Bethesda, Maryland, 20892
United States

Collaborators and Investigators

Sponsor: National Cancer Institute (NCI)

  • Arun Rajan, M.D., PRINCIPAL_INVESTIGATOR, National Cancer Institute (NCI)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2014-05-28
Study Completion Date2029-12-31

Study Record Updates

Study Start Date2014-05-28
Study Completion Date2029-12-31

Terms related to this study

Keywords Provided by Researchers

  • Sample Acquisition
  • Genetic and Epigenetic Alterations
  • Mig6 Expression
  • Proteomic Analysis
  • Genomic Analysis
  • Natural History

Additional Relevant MeSH Terms

  • Non-Small Cell Lung Cancer
  • Small Cell Lung Cancer
  • Extrapulmonary Small Cell Cancer
  • Pulmonary Neuroendocrine Tumors
  • Thymic Epithelial Tumors