Changes Associated With H. Pylori and Gastric Carcinogenesis

Description

This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care. The purpose of this study is to find out how and why H. pylori infections can cause progression to gastric cancer and if it's possible for intervention prior to this progression.

Conditions

Bacterial Infection Due to Helicobacter Pylori (H. Pylori)

Talk to us

Study Overview

On this page

Study Details

Study overview

This is a research study for patients who currently have or previously had an H. pylori infection or who have gastric or esophageal cancer and who plan to undergo an endoscopy as part of their care. The purpose of this study is to find out how and why H. pylori infections can cause progression to gastric cancer and if it's possible for intervention prior to this progression.

Next-Generation Sequencing to Evaluate Transcriptomic Changes Associated With H. Pylori Infection and Gastric Cancer Carcinogenesis

Changes Associated With H. Pylori and Gastric Carcinogenesis

Condition
Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Intervention / Treatment

-

Contacts and Locations

New York

Weill Cornell Medical College, New York, New York, United States, 10021

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patient must be 18 years or older
  • * Patient must have active or prior H. pylori infection, or have been treated for H.pylori infection in the past, as assessed by ELISA (not applicable for the subset of patient controls) or have gastric or esophageal cancer or have Barrett's Esophagus
  • * Patients must be eligible for and are planning to undergo a routine upper endoscopy and tissue biopsy
  • * Patients must sign informed consent
  • * Prior history of upper GI bleed (within 3 months)
  • * Bleeding disorder or coagulopathy
  • * Recent stroke or myocardial infarction (within 3 months)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Weill Medical College of Cornell University,

Manish Shah, MD, PRINCIPAL_INVESTIGATOR, Weill Medical College of Cornell University

Study Record Dates

2025-04