Reversal of Lipid-Induced Insulin Resistance

Description

The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).

Conditions

Insulin Resistance, NAFLD

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Study Overview

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Study Details

Study overview

The purpose of this study is to examine whether weight reduction decreases intramyocellular (IMCL) and hepatic lipid content, and improves insulin sensitivity of muscle and fat tissue in people who are insulin resistant and have a family history of type 2 diabetes. Hepatic mitochondrial oxidation will be assesses using a 3 hour triple tracer study (D7 glucose, 3-13C lactate and 13C4 beta-hydroxybutyrate).

Reversal of Lipid-Induced Insulin Resistance

Reversal of Lipid-Induced Insulin Resistance

Condition
Insulin Resistance
Intervention / Treatment

-

Contacts and Locations

New Haven

Magnetic Resonance Research Center (MRRC), New Haven, Connecticut, United States, 06511

New Haven

Yale Center for Clinical Investigation HRU, New Haven, Connecticut, United States, 06520

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy, sedentary, non-smoking and not taking any medications other than birth control pills.
  • * Hematocrit \>35%
  • * Subjects will have no systemic or organ disease including diabetes.
  • * Subjects will have no history eating disorders.
  • * Women must be using a form of birth control (sexual abstinence, birth control pills, Norplant, IUD or condoms) and will be studied between day 0 and 7 of their menstrual cycle.
  • * Those who are taking birth control pills or have had a hysterectomy may be studied at any time.
  • * Physical activity will be assessed using a standard questionnaire with an activity index cut off at 2.3.
  • * Any subject, who does not fit the inclusion criteria. Including history of eating disorders, any systemic and organ disease including diabetes.
  • * Hematocrit \<35%.
  • * Women of childbearing potential, who are not using contraception (as mentioned above) or who are not abstinent.
  • * Subjects who have a regular exercise regimen will not be enrolled.
  • * Metal implants and/or body piercing, which cannot be removed before the MR studies.

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Kitt Petersen, MD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2034-12