Detection of Brown Adipose Tissue by Magnetic Resonance Imaging

Description

The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using 18F-2-fluoro-2-deoxy-D-glucosefluorodeoxyglucose -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.

Conditions

Obesity

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Study Overview

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Study Details

Study overview

The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using 18F-2-fluoro-2-deoxy-D-glucosefluorodeoxyglucose -PET as gold standard. In this pilot study, MRI and PET imaging of BAT of healthy adult volunteers will be performed on a combined PET/MRI scanner under mild cold condition.

Assessment of MRI Accuracy for the Detection of Brown Adipose Tissue Using 18F-2-fluoro-2-deoxy-D-glucose Fluorodeoxyglucose -PET as a Gold Standard

Detection of Brown Adipose Tissue by Magnetic Resonance Imaging

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Chapel Hill

Biomedical Research Imaging Center, Chapel Hill, North Carolina, United States, 27599-7513

Chapel Hill

Biomedical Research Imaging Center, Chapel Hill, North Carolina, United States, 27599

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Each subject must be fully informed and have signed consent.
  • * BMI \< 34
  • * Normal neurological and psychological development / able to give consent
  • * Willingness to participate in this study
  • * Subjects less than 18 years of age
  • * Severe claustrophobia
  • * Women who are pregnant, nursing an infant or planning to become pregnant in the next 30 days
  • * People who have a condition that makes MRI unsafe for them (for example, cardiac pacemaker, epicardial pacemaker leads, cochlear implants, metal aneurysm clip, iron filings in your eyes or metal halo devices)
  • * Have had radiation therapy or chemotherapy in the 2 months prior to PET scan
  • * Subjects are taking medications that may interfere with BAT detection

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of North Carolina, Chapel Hill,

Rosa Tamara Branca, PhD, PRINCIPAL_INVESTIGATOR, University of North Carolina, Chapel Hill

Study Record Dates

2028-10