Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity

Description

Patients with a total hip replacement may require early revision surgery due to an adverse local tissue reaction or bone resorption that occurs due to wear debris released from the implant. MRI provides a non-invasive biomarker for clinicians and surgeons to detect early adverse synovial reactions which may exist in the absence of clinical symptoms, thus imparting essential information for clinical management. This study will address two of the most commons causes of hip implant failure, including adverse local tissue reaction in implants not traditionally associated with adverse tissue reactions, as well as the presence of aseptic loosening and loss of implant-bone integration.

Conditions

Complications; Arthroplasty, Complications; Arthroplasty, Mechanical

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Study Overview

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Study Details

Study overview

Patients with a total hip replacement may require early revision surgery due to an adverse local tissue reaction or bone resorption that occurs due to wear debris released from the implant. MRI provides a non-invasive biomarker for clinicians and surgeons to detect early adverse synovial reactions which may exist in the absence of clinical symptoms, thus imparting essential information for clinical management. This study will address two of the most commons causes of hip implant failure, including adverse local tissue reaction in implants not traditionally associated with adverse tissue reactions, as well as the presence of aseptic loosening and loss of implant-bone integration.

The Ability Of MRI To Detect Adverse Local Tissue Reaction And Implant Integration As A Function Of Hip Implant Modularity

Using MRI To Detect Soft Tissue Reactions And Implant Integration As Related To Implant Modularity

Condition
Complications; Arthroplasty
Intervention / Treatment

-

Contacts and Locations

New York

Hospital for Special Surgery, New York, New York, United States, 10021

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Have a total hip replacement with a ceramic component undergoing revision for any reason, including recurrent dislocation.
  • 2. Have a metal-on-polyethylene total hip replacement and have repeated dislocation, or
  • 3. Have a metal-on-polyethylene total hip replacement greater than 1 year old, or
  • 4. Have an infected total hip replacement (any surface bearing)
  • 1. Have a total hip replacement with a ceramic component.
  • 2. Have a metal-on-polyethylene total hip replacement.
  • 3. Have your original or revised total hip replacement.
  • 1. Have occupational exposure to cobalt or chromium
  • 2. Presence of MOM or recalled implant
  • 3. Have had a prior revision of your total hip
  • 4. Standard contra-indications to MRI
  • 1. Have occupational exposure to cobalt or chromium.
  • 2. Have cemented components.
  • 3. Presence of a metal-on-metal or recalled implant.
  • 4. Standard contra-indications to MRI.

Ages Eligible for Study

21 Years to 95 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Hospital for Special Surgery, New York,

Matthew F Koff, PhD, PRINCIPAL_INVESTIGATOR, Hospital for Special Surgery, New York

Hollis G Potter, MD, PRINCIPAL_INVESTIGATOR, Hospital for Special Surgery, New York

Study Record Dates

2025-08