Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Description

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

Conditions

Respiratory Disorders

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Study Overview

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Study Details

Study overview

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

Use of Hyperpolarized 129 Xe MR Lung Imaging in Children and Adults

Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

Condition
Respiratory Disorders
Intervention / Treatment

-

Contacts and Locations

Cincinnati

Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States, 45229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 6 and up
  • * Participant must be able to hold breath for up to 16 seconds
  • * History of heart defect
  • * Pregnancy or positive pregnancy test
  • * History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
  • * Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
  • * Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
  • * Participant is claustrophobic and unable to tolerate the imaging.
  • * Standard MRI exclusions (metal, implants)

Ages Eligible for Study

6 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Children's Hospital Medical Center, Cincinnati,

Jason C. Woods, PhD, PRINCIPAL_INVESTIGATOR, Children's Hospital Medical Center, Cincinnati

Study Record Dates

2027-08