Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure

Description

This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease. When it happens, the lungs have trouble carrying out their normal function of getting oxygen into the blood, and removing carbon dioxide from the body. Investigators are conducting this study to see what drinking too much alcohol, using tobacco products, or using drugs (both legal and illegal) may do to lung infections and respiratory failure. Subjects are asked to be in this research study because they are thought to have a lung infection and may also have respiratory failure. Alcohol, tobacco, and drug use have been linked to lung infections, respiratory failure, and even death, but the reasons for this aren't known. People who use unhealthy amounts of alcohol, tobacco, and or drugs may be more at risk for lung infections, and for severe complications due to lung infection. Subject participation is important whether or not you use alcohol and or drugs.

Conditions

Infection, Alcohol Abuse, Drugs of Abuse, Lung Injury

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Study Overview

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Study Details

Study overview

This study plans to learn more about people who are sick in the hospital with a lung infection, or respiratory failure. Respiratory failure, or severe lung failure, is a life-threatening disease. When it happens, the lungs have trouble carrying out their normal function of getting oxygen into the blood, and removing carbon dioxide from the body. Investigators are conducting this study to see what drinking too much alcohol, using tobacco products, or using drugs (both legal and illegal) may do to lung infections and respiratory failure. Subjects are asked to be in this research study because they are thought to have a lung infection and may also have respiratory failure. Alcohol, tobacco, and drug use have been linked to lung infections, respiratory failure, and even death, but the reasons for this aren't known. People who use unhealthy amounts of alcohol, tobacco, and or drugs may be more at risk for lung infections, and for severe complications due to lung infection. Subject participation is important whether or not you use alcohol and or drugs.

Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure

Effect of Alcohol and Drugs of Abuse on Immune Function in Critically Ill Patients With Respiratory Failure

Condition
Infection
Intervention / Treatment

-

Contacts and Locations

Aurora

University of Colorado Hospital, Aurora, Colorado, United States, 80045

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Specific Aim 1: Adult medical ICU patients admitted to the University of Colorado Hospital for a primary respiratory problem, and who are expected to require ICU care ≥48 hrs
  • * Specific Aim 2: (1) Adult medical ICU patients with respiratory failure (due to underlying lung pathology) and who require endotracheal intubation and mechanical ventilation. (2) Adult medical and other ICU patients with respiratory failure, not related to a lung condition, and who require endotracheal intubation and mechanical ventilation. (3) Adult ICU patients previously admitted to the University of Colorado Hospital for a primary respiratory problem, and who required care ≥48 hrs.
  • * Patients who are expected to require ICU care \<48 hrs
  • * Patients admitted to the ICU who are not ICU status (being housed for space issues)
  • * Patient is unlikely to survive 48 hours
  • * Patient is on comfort care (hospice measures)
  • * Patients less than 18 or greater than 90 years of age
  • * Patient is a prisoner
  • * ICU attending declines enrollment of patient
  • * Patients who are pregnant
  • * Patients who have significant anemia, defined as Hgb\<8% or Hct\<24%, or who have evidence of active bleeding.
  • * Patients who are on either a fraction of inspired oxygen inspired oxygen fraction (FiO2)\>80% or positive end expiratory pressure (PEEP) \>10 cm H20
  • * Patients with platelets less than 30,000(chronically)
  • * Patients who are expected to undergo a spontaneous breathing trial within the next 4 hours
  • * Patients with an order or plan to extubate in the next 4 hours
  • * Patients who have an endotracheal tube (ETT) \<7.5 F
  • * Patients who are currently dangerously agitated
  • * Pregnant women
  • 1. Patients who required ICU care \<48 hrs
  • 2. Patients less than 18 or greater than 90 years of age
  • 3. Patient is a prisoner
  • 4. Patients who are pregnant
  • 5. Residency \> 40 miles from UCH clinics
  • 6. non-English or non-Spanish speaking
  • 7. Inability to perform study procedures (i.e. physical disability)
  • 8. unable to perform pulmonary function testing
  • 9. diagnosis of chronic pulmonary disease (e.g. COPD)
  • 10. diagnosis of chronic neurodegenerative disease or severe dementia
  • 11. history of anoxic or traumatic brain injury
  • 12. prior ICU hospitalization at a non-UCH facility.

Ages Eligible for Study

18 Years to 90 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Colorado, Denver,

Ellen L Burnham, MD, PRINCIPAL_INVESTIGATOR, University of Colorado, Denver

Study Record Dates

2029-04-30