RECRUITING

Effects of Breathing Mild Bouts of Low Oxygen on Limb Mobility After Spinal Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Accumulating evidence suggests that repeatedly breathing low oxygen levels for brief periods (termed intermittent hypoxia) is a safe and effective treatment strategy to promote meaningful functional recovery in persons with chronic spinal cord injury (SCI). The goal of the study is to understand the mechanisms by which intermittent hypoxia enhances motor function and spinal plasticity (ability of the nervous system to strengthen neural pathways based on new experiences) following SCI.

Official Title

Mechanisms of Intermittent Hypoxia-induced Motor Recovery in Persons With SCI

Quick Facts

Study Start:2014-10
Study Completion:2024-05
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02323945

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 18 and 75 years (the latter to reduce likelihood of heart disease)
  2. * Medical clearance to participate
  3. * Lesion at or below C2 and above T12 with non-progressive etiology
  4. * Classified as motor-incomplete with visible volitional leg movement
  5. * Injury greater than 1 year
  1. * Concurrent severe medical illness (i.e., infection, cardiovascular disease, ossification, recurrent autonomic dysreflexia, unhealed decubiti, and history of pulmonary complications)
  2. * Pregnant women because of the unknown affects of AIH on pregnant women and fetus
  3. * History of seizures, brain injury, and/or epilepsy
  4. * Undergoing concurrent physical therapy
  5. * Diabetes
  6. * Cirrhosis
  7. * Caffeine and/or NSAID allergies or intolerances

Contacts and Locations

Study Contact

Randy D Trumbower, PT, PhD
CONTACT
617-952-6951
randy.trumbower@mgh.harvard.edu
Stella Barth, BA
CONTACT
617-952-6822
sbarth@partners.org

Principal Investigator

Randy D Trumbower, PT, PhD
PRINCIPAL_INVESTIGATOR
Harvard Medical School (HMS and HSDM)

Study Locations (Sites)

Spaulding Rehabilitation Hospital
Cambridge, Massachusetts, 02138
United States

Collaborators and Investigators

Sponsor: Spaulding Rehabilitation Hospital

  • Randy D Trumbower, PT, PhD, PRINCIPAL_INVESTIGATOR, Harvard Medical School (HMS and HSDM)

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2014-10
Study Completion Date2024-05

Study Record Updates

Study Start Date2014-10
Study Completion Date2024-05

Terms related to this study

Keywords Provided by Researchers

  • acute intermittent hypoxia
  • incomplete spinal cord injury
  • strength
  • walking
  • breathing

Additional Relevant MeSH Terms

  • Spinal Cord Injuries