RECRUITING

PET/MRI, 18F-FDG PET/CT and Whole Body MRI in Finding Extramedullary Myeloid Leukemia in Patients With Newly Diagnosed Acute Myeloid Leukemia

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This pilot phase I trial studies how well positron emission tomography (PET)/magnetic resonance imaging (MRI), fludeoxyglucose F-18 (18F-FDG) PET/computed tomography (CT), and whole body MRI work in finding extramedullary myeloid leukemia in patients with newly diagnosed acute myeloid leukemia. Extramedullary myeloid leukemia is a type of cancer found outside of the bone marrow and can be hard to detect with routine bone marrow monitoring, such as bone marrow aspirations. Diagnostic procedures, such as PET/MRI, 18F-FDG PET/CT and whole body MRI, may help find and diagnose extramedullary myeloid leukemia in patients with newly diagnosed acute myeloid leukemia.

Official Title

PET/MR, PET/CT and Whole Body MR in Newly Diagnosed Acute Myeloid Leukemia (AML)

Quick Facts

Study Start:2020-07-15
Study Completion:2025-09-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02390635

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients with newly diagnosed AML
  2. * Non-English speaking subjects will be included. Verbal Translation Preparative Sheet (VTPS) short form will be utilized in consenting non-English speaking subjects.
  1. * Patients with contraindications to MR
  2. * Patients with a known allergy to MR contrast agents
  3. * Uncontrollable claustrophobia
  4. * Recipients of more than minimal anti-leukemia treatment, with minimal treatment defined as: leukapheresis, hydroxyurea, or Cytarabine more than 1 g per square meter.
  5. * Patients with secondary or relapsed AML or APL should be excluded.
  6. * Patients with known extramedullary leukemia
  7. * Positive pregnancy test in a female of childbearing potential
  8. * Younger than 18 years
  9. * Greater than 400 pounds in weight
  10. * Patients with uncontrolled diabetes
  11. * Cognitive impaired adults or prisoners will be excluded
  12. * Estimated glomerular filtration rate (eGFR \<30) will be excluded

Contacts and Locations

Study Contact

Dawid Schellingerhout, MD
CONTACT
(713) 794-5673
dawid.schellingerhout@mdanderson.org

Principal Investigator

Dawid Schellingerhout
PRINCIPAL_INVESTIGATOR
M.D. Anderson Cancer Center

Study Locations (Sites)

M D Anderson Cancer Center
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: M.D. Anderson Cancer Center

  • Dawid Schellingerhout, PRINCIPAL_INVESTIGATOR, M.D. Anderson Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-07-15
Study Completion Date2025-09-15

Study Record Updates

Study Start Date2020-07-15
Study Completion Date2025-09-15

Terms related to this study

Additional Relevant MeSH Terms

  • Acute Myeloid Leukemia
  • Acute Promyelocytic Leukemia With PML-RARA