RECRUITING

Sympatholysis in Chronic Kidney Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

Official Title

Functional Sympatholysis and Exercise Intolerance in Chronic Kidney Disease

Quick Facts

Study Start:2015-06-11
Study Completion:2027-06
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02411773

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 75 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Veterans with Stages III and IV Chronic Kidney Disease (CKD)
  2. * Veterans 18-75 years old, without kidney disease, as study controls
  3. * Exercise less than 20 minutes twice per week
  4. * Willing and able to cooperate with the protocol
  1. * Severe CKD (estimated glomerular filtration rate (eGFR) \< 15 cc/minute)
  2. * Metabolic alkalosis (serum bicarbonate \> 28 meq/L)
  3. * Ongoing drug or alcohol abuse
  4. * Diabetic neuropathy
  5. * Any serious systemic disease that might influence survival
  6. * Severe anemia with hemoglobin (Hbg) level \< 10 g/dL
  7. * Clinical evidence of congestive heart failure or ejection fraction below 35%
  8. * Symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history
  9. * Treatment with central alpha agonists (clonidine)
  10. * Uncontrolled hypertension with blood pressure (BP) greater than 170/100 mmHg
  11. * Low blood pressure with BP less than 100/50 mmHg
  12. * Pregnancy or plans to become pregnant
  13. * Current treatment with monoamine oxidase inhibitors (MAOIs)
  14. * Inability to exercise on a stationary bicycle

Contacts and Locations

Study Contact

Dana DaCosta
CONTACT
404-727-7762
drdacos@emory.edu
Jeanie Park, MD
CONTACT
404-321-6111

Principal Investigator

Jeanie Park, MD
PRINCIPAL_INVESTIGATOR
Emory University

Study Locations (Sites)

Atlanta VA Medical Center
Decatur, Georgia, 30033
United States

Collaborators and Investigators

Sponsor: Emory University

  • Jeanie Park, MD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2015-06-11
Study Completion Date2027-06

Study Record Updates

Study Start Date2015-06-11
Study Completion Date2027-06

Terms related to this study

Additional Relevant MeSH Terms

  • Chronic Kidney Disease