Sympatholysis in Chronic Kidney Disease

Description

The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

Conditions

Chronic Kidney Disease

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Study Overview

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Study Details

Study overview

The purpose of this study is to find out why patients with chronic kidney disease (CKD) have poor exercise capacity and what causes an increase in blood pressure during exercise (i.e. increased adrenaline levels, or decreased ability of blood vessels to dilate).

Functional Sympatholysis and Exercise Intolerance in Chronic Kidney Disease

Sympatholysis in Chronic Kidney Disease

Condition
Chronic Kidney Disease
Intervention / Treatment

-

Contacts and Locations

Decatur

Atlanta VA Medical Center, Decatur, Georgia, United States, 30033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Veterans with Stages III and IV Chronic Kidney Disease (CKD)
  • * Veterans 18-75 years old, without kidney disease, as study controls
  • * Exercise less than 20 minutes twice per week
  • * Willing and able to cooperate with the protocol
  • * Severe CKD (estimated glomerular filtration rate (eGFR) \< 15 cc/minute)
  • * Metabolic alkalosis (serum bicarbonate \> 28 meq/L)
  • * Ongoing drug or alcohol abuse
  • * Diabetic neuropathy
  • * Any serious systemic disease that might influence survival
  • * Severe anemia with hemoglobin (Hbg) level \< 10 g/dL
  • * Clinical evidence of congestive heart failure or ejection fraction below 35%
  • * Symptomatic heart disease determined by prior electrocardiogram, stress test, and/or history
  • * Treatment with central alpha agonists (clonidine)
  • * Uncontrolled hypertension with blood pressure (BP) greater than 170/100 mmHg
  • * Low blood pressure with BP less than 100/50 mmHg
  • * Pregnancy or plans to become pregnant
  • * Current treatment with monoamine oxidase inhibitors (MAOIs)
  • * Inability to exercise on a stationary bicycle

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Emory University,

Jeanie Park, MD, PRINCIPAL_INVESTIGATOR, Emory University

Study Record Dates

2027-06