F 18 T807 Tau PET Imaging of Alzheimer's Disease

Description

A single-center, open-label baseline controlled imaging study designed to assess whether brain tau fibril uptake of flortaucipir as measured by PET correlates with cognitive status of individuals with and without brain tau fibrils.

Conditions

Alzheimer Disease

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Study Overview

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Study Details

Study overview

A single-center, open-label baseline controlled imaging study designed to assess whether brain tau fibril uptake of flortaucipir as measured by PET correlates with cognitive status of individuals with and without brain tau fibrils.

F 18 T807 Tau PET Imaging of Alzheimer's Disease [IND# 123119] Protocol A

F 18 T807 Tau PET Imaging of Alzheimer's Disease

Condition
Alzheimer Disease
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Washington University School of Medicine, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Male or female participants, at least 18 years of age.
  • 2. Cognitively normal, or with mild dementia, as assessed clinically
  • 3. Participant is able and willing to undergo testing (MRI or CT, PET, radioactive tracer injection, LP; for those unable to undergo an MRI, CT will be used to generate regions-of-interest).
  • 4. Pre-menopausal women will undergo a urine pregnancy test within 24 hours of drug administration.
  • 1. Has any condition that, in the Investigator's opinion, could increase risk to the participant, limit the participant's ability to tolerate the experimental procedures, or interfere with the collection/analysis of the data (for example, participants with severe chronic back pain might not be able to lie still during the scanning procedures).
  • 2. Is deemed likely unable to perform the imaging procedures for any reason.
  • 3. Has a high risk for Torsades de Pointes or is taking medications known to prolong QT interval.
  • 4. Has hypersensitivity to F 18 T807 or any of its excipients.
  • 5. Contraindications to PET, PET-CT or MR (e.g. electronic medical devices, inability to lie still for long periods) that make it unsafe for the individual to participate.
  • 6. Severe claustrophobia.
  • 7. Currently pregnant or breast-feeding.
  • 8. For those electing to undergo the optional lumbar puncture: currently on anticoagulant of any form -

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Tammie L. S. Benzinger, MD, PhD,

Tammie Benzinger, MD, PhD, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

2024-12