Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects

Description

Abdominal wall transplantation surgery is the transfer of abdominal wall tissues from a deceased human donor to a patient with a large abdominal wall defect. Abdominal wall transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of patients with large abdominal wall defects. The purpose of this study is to develop the best practices for abdominal wall transplantation that will improve the outcomes of future abdominal wall transplant recipients.

Conditions

Abdominal Wall Defect

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Study Overview

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Study Details

Study overview

Abdominal wall transplantation surgery is the transfer of abdominal wall tissues from a deceased human donor to a patient with a large abdominal wall defect. Abdominal wall transplantation is an innovative reconstructive procedure that has the potential to significantly improve the lives of patients with large abdominal wall defects. The purpose of this study is to develop the best practices for abdominal wall transplantation that will improve the outcomes of future abdominal wall transplant recipients.

Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects

Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects

Condition
Abdominal Wall Defect
Intervention / Treatment

-

Contacts and Locations

Boston

Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Abdominal wall defects as described above
  • * Strong motivation to proceed with transplantation
  • * Accepts dedicating at least 2 years towards extensive post transplant rehabilitation
  • * Age between 18 and 60 years
  • * Elapsed injury-to-transplant time of more than 6 months and less than 15 years
  • * Reports sub-optimal outcome with conventional reconstructive procedures
  • * Normal liver and kidney function tests:
  • * Record of poor compliance
  • * Unable to receive adequate follow-up care
  • * Unable to receive immune suppression either due to geographic or financial limitations
  • * Unable to follow strict rehabilitation schedule.
  • * Documented psychological disorder(s) or incomplete psychological clearance
  • * Impaired renal or hepatic function
  • * Active cancer with or without metastases
  • * Severe cardiac/pulmonary dysfunction or other severe irreversible/uncorrectable disease

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Brigham and Women's Hospital,

Bohdan Pomahac, MD, PRINCIPAL_INVESTIGATOR, Brigham and Women's Hospital

Study Record Dates

2025-02