Safety and Durability of Sirolimus for Treatment of LAM

Description

The MIDAS study aims to follow male and female LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.

Conditions

Lymphangioleiomyomatosis

Study Overview

Study Details

Study overview

The MIDAS study aims to follow male and female LAM patients who are currently taking, have previously failed or been intolerant of, or may (at some time in the future) take mTOR inhibitors (sirolimus or everolimus) as part of their clinical care. Adult female TSC patients may also enroll, with or without lung cysts.

Multicenter International Durability and Safety of Sirolimus in LAM Trial (MIDAS)

Safety and Durability of Sirolimus for Treatment of LAM

Condition
Lymphangioleiomyomatosis
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford University Medical Center, Stanford, California, United States, 94305

Denver

National Jewish Health, Denver, Colorado, United States, 80206

Jacksonville

Mayo Clinic Jacksonville, Jacksonville, Florida, United States, 32224

Atlanta

Emory University School of Medicine, Atlanta, Georgia, United States, 33136

Maywood

Loyola University Medical Center, Chicago, Maywood, Illinois, United States, 60153

Boston

Brigham and Women's Hospital, Boston, Massachusetts, United States, 02115

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Rochester

Mayo Clinic Rochester, Rochester, Minnesota, United States, 55905

Saint Louis

Washington University School of Medicine, Saint Louis, Missouri, United States, 63110

Rochester

University of Rochester Medical Center, Rochester, New York, United States, 14642-8692

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Female or male, age 18 or over
  • * Diagnosis of LAM based on ATS/JRS criteria
  • * Signed and dated informed consent
  • * On chronic therapy, newly treated or may be considered for therapy with mTOR inhibitors or previously intolerant of or having failed mTOR inhibitor therapy
  • * Inability to attend at least one RLD Clinic visit per year
  • * Inability to give informed consent
  • * Inability or unwillingness to perform pulmonary function testing

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Cincinnati,

Francis X McCormack, MD, STUDY_DIRECTOR, University of Cincinnati

Study Record Dates

2025-07-31