Differing Levels of Hypoglycemia

Description

Hypoglycemia can produce a spectrum of pro-inflammatory and pro-atherothrombotic changes. To date no studies appear to have investigated the effects of differing levels of hypoglycemia on the vasculature and pro-atherothrombotic balance during hypoglycemia in healthy man. The specific aim of our study will be to determine the effects of differing levels of hypoglycemia on in-vivo vascular biologic mechanisms in a healthy population.

Conditions

Hypoglycemia

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Study Overview

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Study Details

Study overview

Hypoglycemia can produce a spectrum of pro-inflammatory and pro-atherothrombotic changes. To date no studies appear to have investigated the effects of differing levels of hypoglycemia on the vasculature and pro-atherothrombotic balance during hypoglycemia in healthy man. The specific aim of our study will be to determine the effects of differing levels of hypoglycemia on in-vivo vascular biologic mechanisms in a healthy population.

Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Differing Levels of Hypoglycemia

Differing Levels of Hypoglycemia

Condition
Hypoglycemia
Intervention / Treatment

-

Contacts and Locations

Baltimore

University of Maryland, Baltimore, Baltimore, Maryland, United States, 21201

Baltimore

University of Maryland, Baltimore, Baltimore, Maryland, United States, 21201

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Pregnant women
  • * Subjects unwilling or unable to comply with approved contraception measures
  • * Subjects unable to give voluntary informed consent
  • * Subjects on anticoagulant drugs, anemic or with known bleeding diatheses
  • * Subjects with a history of severe, uncontrolled hypertension, heart disease, cerebrovascular incidents
  • * Current tobacco use
  • * Subjects with any known allergies to any of the study medications being used
  • * Uncontrolled severe hypertension (i.e., blood pressure greater than 160/100)
  • * Clinically significant cardiac abnormalities (e.g. heart failure, arrhythmia)
  • * Pneumonia treatment or hospitalization within 2 weeks prior to enrollment (study visit)
  • * Hepatic failure / jaundice
  • * Renal failure
  • * Cerebrovascular accident occurrence or hospitalization within 4 weeks prior to enrollment
  • * Fever greater than 38.0 degrees C
  • * Hematocrit lower than 32 %
  • * White blood cell (WBC) count lower than 3 thou/ul or greater than 14 thou/ul
  • * Liver function tests: serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT) greater than twice upper limit of normal range
  • * Alkaline phosphatase greater than 150U/L
  • * Total bilirubin (TBil) greater than 2 mg/dl
  • * Estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m2
  • * Positive human immunodeficiency virus (HIV), Hepatitis B or Hepatitis C
  • * Any abnormal cardiac response during multi-stage exercise test (if over 40 years of age)

Ages Eligible for Study

18 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Maryland, Baltimore,

Study Record Dates

2026-12