RECRUITING

Corticospinal Function After Spinal Cord Injury

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The investigator's overall goal is to develop new strategies to test optimization of Spike-timing-dependent plasticity (STDP) doses to maximize strategy to restore upper and lower-limb motor function in individuals with spinal cord injury (SCI). The investigator proposes to use modern electrophysiological methods to enhance the efficacy of residual corticospinal connections. Defining the neural basis by which corticospinal volleys generate muscle responses will provide crucial information required to maximize residual motor output. The investigator's specific goals are to: 1) determine the temporal and spatial organization of corticospinal volleys and motor cortical representations of upper-limb muscles after incomplete cervical SCI and 2) develop methodologies to promote recovery of function. The investigator's focus on reach and grasp movements because of their importance in daily life activities.

Official Title

Corticospinal Function After Spinal Cord Injury

Quick Facts

Study Start:2020-10-12
Study Completion:2026-12-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02451683

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Inclusion criteria for individuals with SCI:
  2. 1. Male and females between 18-85 years,
  3. 2. Chronic SCI (≥ 6 months post injury),
  4. 3. Cervical injury at C8 or above,
  5. 4. Intact or impaired but not absent innervations in dermatomes C6, C7, and C8 using the American Spinal Injury Association sensory scores, and
  6. 5. Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk
  7. 1. Male and females between 18-85 years,
  8. 2. Right handed,
  9. 3. Ability to reach and grasp a small object located at least 8 cm forward, above, and laterally without leaning forward with the trunk
  1. * Exclusion criteria for individuals with SCI and Healthy Controls:
  2. 1. Uncontrolled medical problems including pulmonary, cardiovascular or orthopedic disease
  3. 2. Any debilitating disease prior to the SCI that caused exercise intolerance
  4. 3. Premorbid, ongoing major depression or psychosis, altered cognitive status
  5. 4. History of head injury or stroke
  6. 5. Pacemaker
  7. 6. Metal plate in skull
  8. 7. History of seizures
  9. 8. Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants
  10. 9. Pregnant females
  11. 10. Ongoing cord compression or a syrinx in the spinal cord or who suffer from a spinal cord disease such as spinal stenosis, spina bifida or herniated cervical disk.
  12. 11. History of brain tumor and or brain infection

Contacts and Locations

Study Contact

Monica A Perez, PhD, PT
CONTACT
312-238-2886
mperez04@sralab.org

Principal Investigator

Monica Perez, PT PhD
PRINCIPAL_INVESTIGATOR
Shirley Ryan AbilityLab

Study Locations (Sites)

Shirley Ryan AbilityLab
Chicago, Illinois, 60611
United States

Collaborators and Investigators

Sponsor: Shirley Ryan AbilityLab

  • Monica Perez, PT PhD, PRINCIPAL_INVESTIGATOR, Shirley Ryan AbilityLab

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-10-12
Study Completion Date2026-12-30

Study Record Updates

Study Start Date2020-10-12
Study Completion Date2026-12-30

Terms related to this study

Keywords Provided by Researchers

  • SCI

Additional Relevant MeSH Terms

  • Spinal Cord Injury