Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome

Description

The investigators are testing treatment with low-dose naltrexone (LDN) for symptom relief of complex regional pain syndrome (CRPS). Study participants will be randomly assigned to receive either LDN or placebo for a period of several weeks. During this period participants will be asked to attend either in-person or virtual study visits and complete questionnaires.

Conditions

Complex Regional Pain Syndrome

Study Overview

Study Details

Study overview

The investigators are testing treatment with low-dose naltrexone (LDN) for symptom relief of complex regional pain syndrome (CRPS). Study participants will be randomly assigned to receive either LDN or placebo for a period of several weeks. During this period participants will be asked to attend either in-person or virtual study visits and complete questionnaires.

Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome

Low-Dose Naltrexone for the Treatment of Complex Regional Pain Syndrome

Condition
Complex Regional Pain Syndrome
Intervention / Treatment

-

Contacts and Locations

Palo Alto

Stanford University, Palo Alto, California, United States, 94304

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Upper and/or lower extremity CRPS
  • * On stable treatment for 1 month
  • * CRPS for at least 1 year
  • * Meet the Budapest criteria for CRPS at time of the study.
  • * Any known allergy to naltrexone or naloxone
  • * Use of prescription opioid analgesics or illegal opioid use
  • * Current or planned pregnancy.

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Sean Mackey, MD, PhD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2025-06