Natural History and Genetics of Food Allergy and Related Conditions

Eligibility Criteria

• 1. Be 2 to 99 years-old at the time of enrollment for participants who will be seen at the NIH CC; be 0 (newborn) to 99 years-old at the time of enrollment for participants who will submit mail-in samples or participate in telehealth visits. Only viable neonates will be enrolled.
• 2. Willing to allow storage of blood, buccal swabs, saliva, nasal swabs, stool samples, and other clinically appropriate tissue specimens for future use in medical research
• 3. Required to have a primary care or other physician who will manage all health conditions related or unrelated to the study objectives
• 1. Have a clinical history of an immediate hypersensitivity reaction to food(s) and be sensitized to food allergen(s) (as evidenced by positive SPT or allergen-specific IgE testing)
• 2. Be sensitized (as evidenced by positive SPT or allergen-specific IgE testing) to food allergen(s) but have no overt clinical history of IgE-mediated symptoms when they eat that food(s)
• 3. Have a suspected genetic or congenital disorder potentially associated with food allergy or related condition, as determined by the principal investigator (PI) or associate investigators (AIs)
• 4. Have a diagnosis of eosinophilic esophagitis (EoE), or clinical suspicion for EoE as determined by the principal investigator (PI) or associate investigators (AIs)
• 5. Have a history of atopic dermatitis based on self-report or physician assessment.
• 1. Be a relative of an affected participant
• 2. Be unaffected by food allergy (as determined by clinical history and/or allergy testing) or be unaffected by the genetic condition under study
• 1. Be unrelated to an affected participant
• 2. Be unaffected by food allergy (as determined by clinical history and/or allergy testing) or be unaffected by the genetic condition under study
• * Presence of conditions that, in the judgment of the investigator or the referring physician, may put the participant at undue risk or make them unsuitable for participation in the study.
• * Inability to participate for the duration of the study.
• * The PI deems that participation in the study would not be expected to advance the study goals.
• 1. uncontrolled asthma or Grade 3 or higher by the American Society of Anesthesiologist s. Physical Status Classification System (http://www.asahq.org/resources/clinicalinformation/.asa-physical-status-classification-system)
• 2. history of adverse reaction to conscious sedation or general anesthesia required for endoscopy
• 3. hemoglobin \< 11 g/dL
• 4. platelet count \< 100,000 microL
• 5. PT INR \>1.3 or PTT prolonged by \> 3 seconds
• 6. pregnant or breastfeeding
• 7. viral screens positive for HIV or hepatitis B or C
• 8. severe unstable myocardial ischemia or cardiomyopathy
• 9. severe hypoxemia due to chronic pulmonary disease
• 10. recent abdominal surgery
• 11. anticoagulant therapy that cannot be interrupted
• 12. history of reflux disease within the last 3 years or use of acid-suppression medication (including over-the-counter medications such as Tums, Rolaids, Zantac, Prilosec OTC, or Prevacid OTC) within the last 2 months
• 13. chronic GI or immunologic disease
• 14. clinically indicated EGD or colonoscopy within the past 12 months
• 15. use of systemic or inhaled corticosteroids within the past 4 months
• 16. have a history of EGID including EoE
• 17. younger than 18 years of age