Use of CXCL9 as a Biomarker of Acthar Efficacy

Description

The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9).

Conditions

Sarcoidosis

Study Overview

Study Details

Study overview

The objective is this study is to test whether use of Acthar gel in the context of sarcoidosis will lead to improved symptoms and lung function and correlate with decreased levels of predictive blood biomarkers, like chemokine ligand 9 (CXCL9).

Use of CXCL9 as a Biomarker of Acthar Efficacy

Use of CXCL9 as a Biomarker of Acthar Efficacy

Condition
Sarcoidosis
Intervention / Treatment

-

Contacts and Locations

San Francisco

University of California, San Francisco, San Francisco, California, United States, 94143

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Biopsy-proven diagnosis of sarcoidosis with demonstrated pulmonary involvement
  • * Refractoriness to or intolerance of immunosuppressive agents like prednisone or methotrexate
  • * Smoking
  • * Cancer
  • * Chronic infections (e.g. tuberculosis, viral, fungal, bacterial)
  • * Inflammatory conditions
  • * Coexisting lung disease
  • * Congestive heart failure
  • * Uncontrolled hypertension
  • * Recent surgery
  • * Active peptic ulcers
  • * Osteoporosis

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Francisco,

Laura Koth, MD, PRINCIPAL_INVESTIGATOR, University of California, San Francisco

Study Record Dates

2026-12