OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

Description

The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with EoE, EoG, EoN and EoC normally undergo endoscopy and/or colonoscopy where cells are collected for microscopic analysis. Treatments are then decided based on how the cells look. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms. We want to see if scores on standard questionnaires can give us an idea how well the person is doing.

Conditions

Eosinophilic Gastrointestinal Disorders (EGIDs), Eosinophilic Esophagitis, Eosinophilic Gastritis, Eosinophilic Gastroenteritis, Eosinophilic Colitis

Study Overview

Study Details

Study overview

The purpose of this observational study is to find the best measures to define how well a person with eosinophilic disorder is doing. People with EoE, EoG, EoN and EoC normally undergo endoscopy and/or colonoscopy where cells are collected for microscopic analysis. Treatments are then decided based on how the cells look. We are aiming to compare different tissue components such as inflammatory cell types with clinical symptoms. We want to see if scores on standard questionnaires can give us an idea how well the person is doing.

A Prospective, Multicenter Study to Compare and Validate Endoscopic, Histologic, Molecular, and Patient-Reported Outcomes in Pediatric and Adult Patients With Eosinophilic Esophagitis (EoE), Gastritis (EoG), Enteritis (EoN) and Colitis (EoC)

OMEGA: Outcome Measures in Eosinophilic Gastrointestinal Disorders Across the Ages

Condition
Eosinophilic Gastrointestinal Disorders (EGIDs)
Intervention / Treatment

-

Contacts and Locations

Phoenix

Mayo Clinic Hospital, Phoenix, Arizona, United States, 85054

Rogers

Arkansas Children's Research Institute, Rogers, Arkansas, United States, 72758

San Diego

Rady Children's Hospital, San Diego, California, United States, 92123

Aurora

University of Colorado Denver, Aurora, Colorado, United States, 80045

Denver

Children's Hospital Colorado, Denver, Colorado, United States, 80218

Chicago

Northwestern University, Chicago, Illinois, United States, 60208

Chicago

Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States, 60611

Indianapolis

Riley Children's Hospital, Indianapolis, Indiana, United States, 46202

Bethesda

National Institutes of Health (NIH), Bethesda, Maryland, United States, 20892

Boston

Tufts University, Boston, Massachusetts, United States, 02111

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Males or females 3 years of age and older
  • * Mucosal eosinophilia:
  • * History of intestinal surgery other than G tube placement
  • * Enrolled in a blinded investigational study at the time of the first study visit
  • * Have esophageal stricture (\<3mm)
  • * Have other identifiable causes for eosinophilia (except Inflammatory Bowel Disease): infections, Gastrointestinal (GI) cancer, other GI inflammatory disease (e.g., Ulcerative Colitis or Crohn\'s Disease)

Ages Eligible for Study

3 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Children's Hospital Medical Center, Cincinnati,

Marc E Rothenberg, MD, PhD, PRINCIPAL_INVESTIGATOR, Cincinnati Children's Hospital Medical Center

Study Record Dates

2051-01-01