Autologous Bone Marrow Aspirate Concentrate in Patients Undergoing Meniscectomy

Description

The proposed research study aims to evaluate the effects of autologous bone marrow aspirate concentrate (BMAC) on the development and progression of osteoarthritis (OA) in patients undergoing meniscectomy. This prospective, randomized, double-blind clinical trial will compare patient-reported outcomes, specifically IKDC scores between patients who receive BMAC post-meniscectomy and those who receive a saline control injection. The study will also compare physical examination, MRI, radiographs, and synovial fluid analysis. Our hypothesis is that those who receive the autologous BMAC injection after the procedure will have better outcomes than those who do not.

Conditions

Osteoarthritis Post-meniscectomy

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Study Overview

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Study Details

Study overview

The proposed research study aims to evaluate the effects of autologous bone marrow aspirate concentrate (BMAC) on the development and progression of osteoarthritis (OA) in patients undergoing meniscectomy. This prospective, randomized, double-blind clinical trial will compare patient-reported outcomes, specifically IKDC scores between patients who receive BMAC post-meniscectomy and those who receive a saline control injection. The study will also compare physical examination, MRI, radiographs, and synovial fluid analysis. Our hypothesis is that those who receive the autologous BMAC injection after the procedure will have better outcomes than those who do not.

Prospective, Randomized, Double-blind Clinical Trial to Investigate the Efficacy of Autologous Bone Marrow Aspirate Concentrate Post-Meniscectomy

Autologous Bone Marrow Aspirate Concentrate in Patients Undergoing Meniscectomy

Condition
Osteoarthritis Post-meniscectomy
Intervention / Treatment

-

Contacts and Locations

Chicago

Rush University Medical Center, Chicago, Illinois, United States, 60612

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subject is greater than 18 years old
  • * Written informed consent is obtained
  • * Subject is determined to have a symptomatic meniscal tear requiring a meniscectomy
  • * Meniscal pathology is confirmed through MRI and arthroscopically
  • * Subject agrees to all follow-up evaluations
  • * Osteoarthritis Kellen-Lawrence grade 1-3 on flexion PA and extension AP views
  • * Any subject lacking decisional capability
  • * Unwillingness to participate in the necessary follow-up
  • * Subject is pregnant or may become pregnant
  • * History of diabetes mellitus
  • * History of rheumatoid arthritis or other autoimmune disorder
  • * History of solid organ or hematologic transplantation
  • * Diagnosis of a non-basal cell malignancy within the preceding 5 years
  • * Infection requiring antibiotic treatment within the preceding 3 months
  • * Osteoarthritis Kellen-Lawrence grade 4 on flexion posterior-anterior (PA) or extension anteroposterior (AP) views
  • * Prior surgery on the index meniscus
  • * Concomitant surgery such as ligament surgery or cartilage repair or restoration
  • * Infection
  • * Prior cortisone/viscosupplementation/ (platelet rich plasma) PRP injection within 6 weeks

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Rush University Medical Center,

Brian J Cole, MD, MBA, PRINCIPAL_INVESTIGATOR, Midwest Orthopaedics at Rush

Study Record Dates

2025-12-31