RECRUITING

Aging, Geriatric Syndromes and Clonal Hematopoiesis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

In this study the investigators will incorporate a wide range of clinical variables associated with aging and cardiovascular disease to determine whether they are associated with mutation status independent of chronologic age. Clinically, aging can be operationalized using geriatric assessment, which entails a comprehensive multi-dimensional assessment of the health of an older adult, including measures of comorbidity, polypharmacy, functional status, cognition, depression, falls, social activities and social support. Given that aging is heterogeneous, geriatric assessment allows greater specificity for aging than chronological age alone.

Official Title

Aging, Geriatric Syndromes and Clonal Hematopoiesis

Quick Facts

Study Start:2016-03-10
Study Completion:2030-04-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT02604563

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * At least 50 years of age.
  2. * Able to understand written and spoken English.
  3. * Able to understand and willing to sign an IRB-approved written informed consent document (or that of a legally authorized representative, if applicable for the trauma cohort)
  1. * Inability or unwillingness to complete health questionnaire.
  2. * History of a recent (\<30 days) acute viral illness.
  3. * Current cancer diagnosis and currently receiving chemotherapy or undergoing radiation therapy. A prior history of cancer is allowed if the participant completed therapy \> 1 year prior to enrollment; participants with a prior diagnosis of cancer will be asked to sign a release of information for the research team to obtain records regarding their prior cancer treatment.
  4. * Current use of drugs that cause DNA damage (e.g. Cytoxan, azathioprine, etc.) for the treatment of a non-malignant disease.
  5. * Vulnerable populations (e.g. prisoners).
  6. * Known infection with Hepatitis B or C, HTLV, or HIV.
  7. * Additional exclusion for optional bone marrow aspirate/biopsy substudy:
  8. * Use of medications for anticoagulation or "blood thinning" including warfarin, low molecular weight heparins (enoxaparin, daltaparin) or direct-acting oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban or betrixaban)
  9. * allergy to lidocaine or other local anesthetics.

Contacts and Locations

Study Contact

Meagan Jacoby, M.D.
CONTACT
314-747-8439
mjacoby@wustl.edu
Kristina Williams, B.S.
CONTACT
314-362-6963
kjw1@wustl.edu

Principal Investigator

Meagan Jacoby, M.D.
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine

Study Locations (Sites)

Washington University School of Medicine
Saint Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • Meagan Jacoby, M.D., PRINCIPAL_INVESTIGATOR, Washington University School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2016-03-10
Study Completion Date2030-04-30

Study Record Updates

Study Start Date2016-03-10
Study Completion Date2030-04-30

Terms related to this study

Additional Relevant MeSH Terms

  • Geriatrics
  • Aged
  • Geriatric Syndromes
  • Cardiovascular Diseases