Reliability of Pupil Response to Acute Pain

Description

The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.

Conditions

Pain, Osteoarthritis

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Study Overview

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Study Details

Study overview

The purpose of this research study is to test whether researchers can reliably measure the response pupils have when an acute painful stimulus is experienced. Changes in the size of the pupil of the eye can be an indicator of brain activity in a region of the brain that is important for feeling pain.

Reliability of Pupil Response to Acute Pain

Reliability of Pupil Response to Acute Pain

Condition
Pain
Intervention / Treatment

-

Contacts and Locations

Winston-Salem

Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, United States, 27157

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult (18-70)
  • * Pain from hip or knee arthritis of moderate intensity
  • * American Society of Anesthesiologists physical status 1-3
  • * Inability to complete study questionnaires
  • * Pregnancy
  • * Litigation or workers compensation related to hip or knee pain
  • * Taking \> 50 mg morphine equivalents/day
  • * History of Raynaud's disease of the feet
  • * Psychotic disorder or a recent psychiatric hospitalization
  • * History of eye surgery or topical eye medications that would would directly affect pupil diameter

Ages Eligible for Study

18 Years to 70 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Wake Forest University Health Sciences,

James C Eisenach, MD, PRINCIPAL_INVESTIGATOR, Wake Forest University Health Sciences

Study Record Dates

2025-12